Irisin-induced cardiac fibroblast proliferation is dependent on glucose concentration and is inhibited by WZB117.

Marta Drobnik, Małgorzata Gałdyszyńska, Aleksander Kucner, Jacek Szymański, Marlena Juszczak, Jacek Drobnik

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Marta DrobnikDepartment of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, ul. Żeromskiego 113, Lodz, 90-549, Poland.

Małgorzata GałdyszyńskaLaboratory of Connective Tissue Metabolism, Department of Pathophysiology, Medical University of Lodz, ul. Żeligowskiego 7/9, Lodz, 90-752, Poland.

Aleksander KucnerLaboratory of Connective Tissue Metabolism, Department of Pathophysiology, Medical University of Lodz, ul. Żeligowskiego 7/9, Lodz, 90-752, Poland.

Jacek SzymańskiResearch Laboratory CoreLab, , Medical University of Lodz, Mazowiecka 6/8,, Lodz, 92-215, Poland.

Marlena JuszczakDepartment of Pathophysiology and Experimental Neuroendocrinology, Medical University of Lodz, Żeligowskiego 7/9, Lodz, 90-752, Poland.

Jacek DrobnikLaboratory of Connective Tissue Metabolism, Department of Pathophysiology, Medical University of Lodz, ul. Żeligowskiego 7/9, Lodz, 90-752, Poland. drob@op.pl.

Funding

Uniwersytet Medyczny w Lodzi 503/6-103-04/503-01

6 · The paper itself

Abstract

backgroundsFibroblast proliferation is influenced by inter alia the cellular transport of glucose and its metabolism. The aim of the study is to confirm whether irisin is involved in the regulation of human cardiac fibroblast proliferation, and whether its effect is dependent on glucose concentration or glucose transporter activity (GLUT1). The study also examines the expression of glucose transporters on the cardiac fibroblast cell membrane. METHODS AND

resultsHuman cardiac fibroblasts were cultured under hypoglycemia (1 mmol/l), normoglycemia (5 mmol/l) or hyperglycemia (25 mmol/l), and treated with different concentrations of irisin (10

conclusionIrisin accelerates cardiac fibroblast proliferation and glucose uptake; however, this effect is dependent on glucose concentration and GLUT1 activity. GLUT1, 3 and 4 protein expression was identified on human cardiac fibroblasts.

Indexed as

FibroblastsFibronectinsGlucoseCell ProliferationCells, CulturedGlucose Transporter Type 1Glucose Transporter Type 4Glucose Transport Proteins, FacilitativeHumansHyperglycemiaMyocardiumFibronectinsFNDC5 protein, humanGlucoseGlucose Transporter Type 1Glucose Transporter Type 4Glucose Transport Proteins, FacilitativeSLC2A1 protein, humanCardiac fibroblastsFibrosisGlucose transportersGLUT1GLUT3GLUT4Proliferation

Identifiers

PMID41335262

DOI10.1007/s11033-025-11307-3

PMCPMC12675697

What Socratic holds

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.