Evidence map›Paper›PMID 41335477›Full record

ArticleMicrobial genomics2025

Shotgun metagenomics reveals distinct skin microbial species in allergen-sensitized individuals.

Matilda Riskumäki, Matti O Ruuskanen, Kuunsäde Mäenpää, Lasse Ruokolainen, Mika J Mäkelä, Pekka Jousilahti, Erkki Vartiainen, Noora Ottman, Tiina Laatikainen, Tari Haahtela and 3 more

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In one paragraph

Article in Microbial genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Matilda RiskumäkiHuman Microbiome Research Program, University of Helsinki, Helsinki, Finland.
Matti O RuuskanenDepartment of Computing, University of Turku, Turku, Finland.
Kuunsäde MäenpääHuman Microbiome Research Program, University of Helsinki, Helsinki, Finland.
Lasse RuokolainenDepartment of Biosciences, University of Helsinki, Helsinki, Finland.
Mika J MäkeläSkin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Pekka JousilahtiDepartment of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland.
Erkki VartiainenDepartment of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland.
Noora OttmanNational Food Institute, Technical University of Denmark, Kgs Lyngby, Denmark.
Tiina LaatikainenDepartment of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland.
Tari HaahtelaSkin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Harri AleniusHuman Microbiome Research Program, University of Helsinki, Helsinki, Finland.
Nanna FyhrquistInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Hanna SinkkoHuman Microbiome Research Program, University of Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Karelian region, which spans the border between Finland and Russia, presents distinct environmental exposures and lifestyles on either side of the governmental border. In the more urbanized Finnish Karelia, allergic diseases are markedly more prevalent than in the more rural Russian Karelia. Prior studies, based on amplicon sequencing, have demonstrated major differences in skin microbiotas between the two populations. However, compositional differences in microbiota between sensitized and non-sensitized (NS) individuals have not been characterized. Here, in a selected population of 112 allergen-sensitized and NS adolescents, we used shotgun metagenomics to characterize the prokaryotic, eukaryotic and viral species in the skin potentially involved in allergic sensitization via distinct environmental exposures. In the more urban Finnish Karelia, the microbiome species composition was associated with IgE-mediated allergen sensitization status, while in the more rural Russian Karelia, the composition was associated with exposure to furry pets. Finnish participants showing high IgE-mediated sensitization to common allergens (allergen-specific IgE >7.5 kU/L) had less

Indexed as

AllergensHypersensitivityMetagenomicsMicrobiotaSkinAdolescentBacteriaChildFemaleFinlandHumansImmunoglobulin EMalasseziaMaleRussiaAllergensImmunoglobulin Eallergic sensitizationenvironmental exposureKarelia allergy studymetagenomicsskin microbiome

Identifiers

PMID41335477
PMCPMC13293315

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.