Evidence mapPaperPMID 41335600Full record

ReviewPLoS pathogens2025

The female reproductive tract-gut axis in gastrointestinal parasitic infection.

Olivia Shorthouse, Alice H Costain, Andrew S MacDonald, Juan F Quintana

Abstract readReview
In one paragraph

Review in PLoS pathogens, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Olivia ShorthouseLydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom.ORCID https://orcid.org/0000-0002-7932-634X
Alice H CostainLydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom.
Andrew S MacDonaldInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
Juan F QuintanaLydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal barrier sites are specialised interfaces that constantly defend against challenges, from tissue damage to infections. When considering these sites, we typically think of the lungs, gut, mouth or skin. However, a site often overlooked is the female reproductive tract (FRT), an equally dynamic mucosal site uniquely tasked with both immune defence and sustaining new life. The FRT undergoes dramatic tissue remodelling and can return to a homeostatic state without scarring - an ability shared only with the oral mucosa and foetal skin. Given the interconnected nature of mucosal systems, disruption of intestinal homeostasis by enteric or systemic infection has broad impacts on systemic immunity, prompting us to consider how such disturbances could impact the FRT.

Indexed as

Gastrointestinal TractGenitalia, FemaleIntestinal Diseases, ParasiticAnimalsFemaleHumans

Identifiers

PMID41335600
PMCPMC12674506

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.