Evidence map›Paper›PMID 41335627›Full record

ArticlePLOS global public health2025

Association between peripheral markers in women with malaria in pregnancy and small newborns: A cross-sectional study.

Maria Inês Dos Santos, Alexsander Rodrigues Carvalho Júnior, Gabriela Mendes de Oliveira, Laura Cordeiro Gomes, Wasim Aluísio Prates Syed, Erika Paula Machado Separovic, Sabrina Epiphanio, Gerhard Wunderlich, Cláudio Romero Farias Marinho, Jamille Gregório Dombrowski

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In one paragraph

Article in PLOS global public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria Inês Dos SantosDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Alexsander Rodrigues Carvalho JúniorDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Gabriela Mendes de OliveiraDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Laura Cordeiro GomesDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Wasim Aluísio Prates SyedDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Erika Paula Machado SeparovicDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Sabrina EpiphanioDepartment of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Gerhard WunderlichDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Cláudio Romero Farias MarinhoDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Jamille Gregório DombrowskiDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1863-1914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in angiogenic proteins play a role in newborn growth potential, and they have been widely studied, but not further explored in malaria research. We aimed to identify maternal peripheral proteins that are associated with newborn growth parameters in the context of malaria in pregnancy. We analysed data and biological samples collected from 386 pregnant women with and without malaria selected from previous cohort study in the Amazon region, Brazil, between 2013 and 2015. ELISAs were used to quantify Ang-1, Ang-2, Tie2, VEGF, sFlt1, VEGFR2, PlGF, sENG, and leptin in peripheral plasma at time of delivery. We generated receiver operating characteristic curves and multivariable logistic regression models to assess the associations of maternal peripheral protein levels with the anthropometric profiles of newborns. Tie2, sFlt1, sENG and leptin were associated to growth parameters in newborns of mothers who had malaria during pregnancy. sFlt1 levels were associated with newborn weight and length, and sENG was associated with newborn length in Plasmodium vivax-infected women. Tie2, sFlt1 and leptin levels were associated with newborn length in Plasmodium falciparum-infected women. Identifying maternal peripheral proteins associated with newborn outcomes might help in understanding biological dynamics of malaria in pregnancy in areas of low transmission, improving future health interventions, and encourage further studies with angiogenic proteins.

Identifiers

PMID41335627
PMCPMC12674551

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.