SynthesisBrazilian dental journal2025
Postoperative pain control after free gingival graft: a systematic review and meta-analysis of RCTS.
Synthesis in Brazilian dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of a phthalocyanine mouthrinse after connective tissue graft surgery for root coverage: a randomized split-mouth clinical trial.Oral and maxillofacial surgery · 2026Trial
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review and meta-analysis evaluated the efficacy of interventions for managing postoperative pain following a free gingival graft (FGG) harvested from the palate. A comprehensive search was conducted in eight major databases, without language restrictions, following PRISMA guidelines. Randomized clinical trials (RCTs) involving adults undergoing FGG and assessing postoperative pain were included. Pain was evaluated using the Visual Analog Scale (VAS). Risk of bias was assessed using the Cochrane RoB 2 tool. The protocol was registered on INPLASY (ID INPLASY2022120077). Among 48 studies, 16 had a low risk of bias, 27 presented some concerns, and 5 showed a high risk, mainly related to blinding and allocation concealment. The analysis identified Leukocyte-Platelet Rich Fibrin (L-PRF) + Sutures as the most effective intervention for pain reduction on Day 1 (-6.80; 95% CI [-7.68, -5.92]) compared to sutures and surgical cement. Additionally, Gelatin Sponge + 0.2% Hyaluronic Acid + Sutures significantly reduced pain (-4.80; 95% CI [-6.03, -3.57]) compared to Gelatin Sponge + Sutures. Heterogeneity among studies was substantial (I² = 78-92%), indicating variability in study designs and outcomes, affecting generalizability. Funnel plot analysis suggested a moderate risk of publication bias, potentially overestimating treatment effects. L-PRF and 0.2% HA gel were the most effective interventions for postoperative pain reduction. Palatal protection plates emerged as a viable alternative in resource-limited settings due to their ease of fabrication and affordability. However, substantial heterogeneity and moderate risk of publication bias highlight the need for further high-quality trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.