Evidence map›Paper›PMID 41337583›Full record

ArticleScience advances2025

Longfei Gao, Desmond Dickson, Huijuan Feng, Chaolin Zhang, Lei Ding

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Longfei GaoColumbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-2331-8471
Desmond DicksonColumbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY 10032, USA.
Huijuan FengDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10027, USA.ORCID 0000-0002-4005-560X
Chaolin ZhangDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10027, USA.
Lei DingColumbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0003-4869-8877

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Complexity and evolution of splicing-regulatory networksR35GM145279 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chaolin Zhang · 2022 to 2026
$4.6M
RNA Regulatory Networks in Neuronal Cell Type Diversity and FunctionR01NS125018 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chaolin Zhang · 2022 to 2026
$3.0M
Understanding the role of stellate cells in the liver hematopoietic stem cell nicheR01HL153487 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DING, LEI · 2020 to 2024
$2.8M
Understanding and targeting bone marrow microenvironment in myelofibrosisR01HL155868 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DING, LEI · 2021 to 2024
$2.3M
Developing Next Generation Genetics for Understanding Hematopoietic Stem Cell BiologyR01GM146061 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DING, LEI, YAZAWA, MASAYUKI · 2022 to 2025
$2.0M
Regulation of hematopoietic stem cells and leukemia stem cells by thrombopoietinR01HL132074 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DING, LEI · 2016 to 2020
$2.0M
Epitranscriptomic regulation in hematopoietic stem cell niche generation and regenerationR01HL178977 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DING, LEI · 2025 to 2025
$697k
Understanding the Nature and Regulation of Extramedullary Hematopoiesis in the LiverR00HL173841 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Longfei Gao · 2025 to 2026
$498k
Understanding the Nature and Regulation of Extramedullary Hematopoiesis in the LiverK99HL173841 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GAO, LONGFEI · 2025 to 2025
$130k
NCI NIH HHS P30 CA013696NHLBI NIH HHS K99 HL173841NHLBI NIH HHS R00 HL173841NHLBI NIH HHS R01 HL132074NHLBI NIH HHS R01 HL153487NHLBI NIH HHS R01 HL155868NHLBI NIH HHS R01 HL178977NIGMS NIH HHS R01 GM146061NIGMS NIH HHS R35 GM145279NINDS NIH HHS R01 NS125018
6 · The paper itself

Abstract

Self-renewing hematopoietic stem cells (HSCs) generate all blood cells and give rise to long-term reconstitution of the hematopoietic system after transplantation, but the molecular mechanisms that specifically regulate HSCs remain poorly defined. Here, we found that HSCs displayed a distinct messenger RNA alternative splicing pattern and preferentially expressed

Indexed as

Cell Self RenewalHematopoietic Stem CellsProteostasisRNA Splicing FactorsAlternative SplicingAnimalsMiceMice, Inbred C57BLMice, KnockoutRbfox2 protein, mouseRNA Splicing Factors

Identifiers

PMID41337583
PMCPMC12674123

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.