ArticleScience advances2025
Single-cell sequencing of rodent ventral pallidum reveals diverse neuronal subtypes with noncanonical interregional continuity.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Ventral pallidal GABAergic neurons control hedonic feeding and obesity.bioRxiv : the preprint server for biology · 2026Article
- BNC2 as a putative transcriptional coordinator linking energy state to neural circuits.iScience · 2026Review
- MeCP2 regulates cell-type-specific functions of depressive-like symptoms in the nucleus accumbens.Experimental & molecular medicine · 2026Article
- Accurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns.NAR genomics and bioinformatics · 2025Article
- A ventral pallidal glutamatergic aversive network encodes abstinence from and reexposure to cocaine.Science advances · 2025Article
- Accurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns.bioRxiv : the preprint server for biology · 2025Article
- Transcriptomic landscape of mammalian ventral pallidum at single-cell resolution.Science advances · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The ventral pallidum (VP) was defined as a basal ganglia nucleus with dense input from ventral striatum. To further investigate its regional identity, we conducted a cross-species transcriptional characterization of VP cell types. We performed single-nucleus RNA sequencing of VP tissue from mice and rats and identified 16 conserved VP neuronal subclasses, including 14 γ-aminobutyric acid-releasing subclasses from three developmental classes. Combining our sequencing data with a spatial atlas revealed that all VP subclasses extended beyond the traditional borders in VP. Integrating our VP data with published striatal, hypothalamic, and extended amygdalar sequencing confirmed that cell types are shared among these regions. Given the role of VP in feeding, we also assessed the transcriptional impact of high-fat diet, which altered expression of genes involved in oxidative phosphorylation and inhibitory signaling. Overall, our results demonstrate that VP is not a transcriptionally discrete nucleus; rather, VP contains cell types with diverse expression patterns overlapping with regions beyond the basal ganglia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.