ArticleRedox biology2025
NADPH oxidase isoform NOX-2 deficiency affects mitochondrial oxygen consumption and metabolic flexibility.
Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Experimental workflows for the accurate identification of mitochondrial redox events.Redox biology · 2026Review
- NOX2 deficiency exacerbates lupus nephritis through activation of NLRP3 inflammasome in neutrophils.Journal of biomedical science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our recent study showed that the intracellular pattern recognition receptor Nlrp3 inflammasome, activated by reactive oxygen species (ROS), regulates metabolism in hematopoietic cells by maintaining proper "tonic activation" of the electron transport chain (ETC) in mitochondria. Therefore, we asked whether a deficiency in the expression of NADPH oxidase isoform NOX-2, a primary source of ROS in hematopoietic cells, would similarly affect mitochondrial function and metabolic adaptation to stress. In this study, we examined how NOX-2 influences ETC, redox balance, and glycolytic adaptation in lineage-negative Sca-1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.