Evidence map›Paper›PMID 41339464›Full record

ArticleScientific reports2025

High concentrations of L-lysine cause mitochondrial damage and necrosis in isolated pancreatic acinar cells.

Eszter T Végh, Zsolt Balla, Ágnes Dágó, Ola Salamah, Brigitta Tóth, Jason Elperin, Steven Speakman, Natalia Shalbueva, Petra Pallagi, Zsolt Rázga and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eszter T VéghDepartment of Pathophysiology, University of Szeged, P.O. Box: 427, Szeged, 6701, Hungary.
Zsolt BallaDepartment of Pathophysiology, University of Szeged, P.O. Box: 427, Szeged, 6701, Hungary.
Ágnes DágóDepartment of Pathophysiology, University of Szeged, P.O. Box: 427, Szeged, 6701, Hungary.
Ola SalamahDepartment of Pathophysiology, University of Szeged, P.O. Box: 427, Szeged, 6701, Hungary.
Brigitta TóthDepartment of Pathophysiology, University of Szeged, P.O. Box: 427, Szeged, 6701, Hungary.
Jason ElperinDavid Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Steven SpeakmanDavid Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Natalia ShalbuevaDavid Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Petra PallagiDepartment of Medicine, University of Szeged, Szeged, Hungary.
Zsolt RázgaDepartment of Pathology, University of Szeged, Szeged, Hungary.
Lóránd KissDepartment of Pathophysiology, University of Szeged, P.O. Box: 427, Szeged, 6701, Hungary.
Anna GukovskayaDavid Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Zoltán RakonczayDepartment of Pathophysiology, University of Szeged, P.O. Box: 427, Szeged, 6701, Hungary. rakonczay.zoltan@med.u-szeged.hu.

Funding

EFOP EFOP-3.6.2-16-2017-00006GINOP GINOP-2.3.2-15-2016-00034Nemzeti Kutatási Fejlesztési és Innovációs Hivatal FK143566Nemzeti Kutatási Fejlesztési és Innovációs Hivatal K135874
6 · The paper itself

Abstract

Intraperitoneal administration of high doses of basic amino acids, such as L-lysine (L-Lys), L-arginine (L-Arg) or L-ornithine (L-Orn) induces acute pancreatitis in rodents. Although the exact mechanism of their action is not fully understood, the role of mitochondria has been implicated. We aimed to investigate the effects of basic amino acids, particularly L-Lys, on isolated pancreatic acinar cells. Isolated mouse or rat pancreatic acinar cells were treated with high concentrations (10-60 mM) of L-Lys, L-Arg or L-Orn. The morphology of acinar mitochondria was observed by electron microscopy. The function of mitochondria was assessed by mitochondrial membrane potential (∆Ψm) and cellular ATP level measurements. Changes in intracellular Ca

Indexed as

Acinar CellsLysineMitochondriaPancreasAdenosine TriphosphateAnimalsArginineCalciumMaleMembrane Potential, MitochondrialMiceNecrosisRatsAdenosine TriphosphateArginineCalciumLysineAcute pancreatitisBasic amino acidsL-arginineL-lysineL-ornithinePancreatic acinar cells

Identifiers

PMID41339464
PMCPMC12775379

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.