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Trial reportEuropean geriatric medicine2026

Cardiovascular and glucose-lowering medication use among older adults: results from 9-year follow-up of the FINGER trial.

Maria Sääskilahti, Emma Aarnio, Esko Levälahti, Jenni Lehtisalo, Miia Kivipelto, Timo Strandberg, Riitta Antikainen, Hilkka Soininen, Tiina Laatikainen, Jaakko Tuomilehto and 3 more

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01041989 (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01041989 naunknown statusnot on this map

Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability

TypeinterventionalSponsorFinnish Institute for Health and WelfareRan2009 to 2025Enrolled1,200ConditionsCognitive Impairment, DementiaArmsNutritional guidance, Exercise, Cognitive training, Reduction of vascular risk factors
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Maria SääskilahtiDepartment of Public Health, Lifestyles and Living Environments, Finnish Institute for Health and Welfare, 00271, Helsinki, Finland. maria.saaskilahti@thl.fi.ORCID http://orcid.org/0000-0003-3206-9128
Emma AarnioSchool of Pharmacy, University of Eastern Finland, 70211, Kuopio, Finland.
Esko LevälahtiDepartment of Public Health, Lifestyles and Living Environments, Finnish Institute for Health and Welfare, 00271, Helsinki, Finland.
Jenni LehtisaloDepartment of Public Health, Lifestyles and Living Environments, Finnish Institute for Health and Welfare, 00271, Helsinki, Finland.
Miia KivipeltoDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 64, Solna, Stockholm, Sweden.
Timo StrandbergUniversity of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Riitta AntikainenResearch Unit of Population Health/Geriatrics, University of Oulu, 90014, Oulu, Finland.
Hilkka SoininenDepartment of Clinical Medicine/Neurology, University of Eastern Finland, 70211, Kuopio, Finland.
Tiina LaatikainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Jaakko TuomilehtoSouth Ostrobothnia Central Hospital, Seinäjoki, Finland.
Alina SolomonDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 64, Solna, Stockholm, Sweden.
Francesca MangialascheDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 64, Solna, Stockholm, Sweden.
Tiia NganduDepartment of Public Health, Lifestyles and Living Environments, Finnish Institute for Health and Welfare, 00271, Helsinki, Finland.

Funding

FORTE 2023-01125Innovative Health Initiative Joint Undertaking (IHI JU) 101132933
6 · The paper itself

Abstract

purposeThis study aimed to investigate the use of antihypertensive, lipid-lowering, antithrombotic, and glucose-lowering medication among the FINGER (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability) population during a 9-year follow-up. Also, the effects of the FINGER intervention on and differences between sexes and age groups in medication use were studied.

methodsMedication data for FINGER participants were retrieved from a national register annually, starting from the study baseline. FINGER was a two-year randomized controlled trial for older adults (n = 1259) at risk of cognitive impairment, who were randomly allocated to a multidomain lifestyle intervention or a control group. The intervention aimed at enhancing healthy lifestyle and to manage and monitor cardiovascular and metabolic risk factors. Generalized Estimation Equations were used to assess longitudinal changes in medication use.

resultsCardiovascular and glucose-lowering medication use was common and increased over time among FINGER participants. The prevalences of medication use did not differ between the intervention and control groups. The use of cardiovascular and glucose-lowering medication was fairly similar between men and women. Older participants used more cardiovascular medication compared to younger participants throughout the follow-up.

conclusionThe increasing use of cardiovascular and glucose-lowering medication in this older population at risk of cognitive impairment reflects increasing cardiovascular and diabetes morbidity, management of these risks and diseases through medication, and possible changes in medical practices. Before drawing further conclusions about the effect of the intervention on medication use, its effect on treatment adjustments should be studied.

trial registrationClinicalTrials.gov, NCT01041989, retrospectively registered 04/01/2010.

Indexed as

Cardiovascular DiseasesCognitive DysfunctionHypoglycemic AgentsAgedAged, 80 and overAntihypertensive AgentsFemaleFinlandFollow-Up StudiesHumansMaleAntihypertensive AgentsHypoglycemic AgentsCardiovascularGlucose-loweringMedication useOlder peopleRegister

Identifiers

PMID41339545
PMCPMC13109183

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.