ArticleAnnals of surgical oncology2026
The Effect of Pelvic Lymph Node Dissection on Cancer-Specific Mortality in Partial Cystectomy According to Eligibility Criteria.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Alcohol Use Disorder versus Adverse In-Hospital Outcomes after Radical Cystectomy and Ileal Conduit Urinary Diversion.Annals of surgical oncology · 2026Article
- Extent of Pelvic Lymph Node Dissection at Partial Cystectomy: Effect on Cancer-Specific Mortality.International journal of urology : official journal of the Japanese Urological Association · 2026Article
- The Effect of Pelvic Lymph Node Dissection on Cancer-Specific Mortality in Partial Cystectomy According to Eligibility Criteria.Annals of surgical oncology · 2026Article
- The effect of chronic kidney disease on adverse in-hospital outcomes after partial nephrectomy.World journal of urology · 2025Article
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study tested the rates of partial cystectomy (PC) according to PC eligibility criteria ( ≤ cT2 stage, tumor ≤ 3 cm, and segmental resection possible), as well as the effect of pelvic lymph node dissection (PLND) at PC on cancer-specific mortality (CSM).
methodsIn the Surveillance, Epidemiology, and End Results (SEER) database (2004-2021), the study identified PC patients according to eligibility criteria and PLND status. Kaplan-Meier (KM) and multivariable Cox regression models (CRMs) addressed CSM after inverse probability of treatment-weighting (IPTW) for age, sex, race, household income, and T stage.
resultsOf 2078 PC patients, only 492 (23.7%) fulfilled all three PC criteria. The remaining 1586 patients fulfilled only two (n = 858, 41.3%), one (n = 614, 29.5%), or none (n = 114, 5.5%) of the three criteria. Overall, 790 (49.8%) patients underwent PLND, with PLND performed for 191 (38.8%) patients who fulfilled all three criteria versus 395 (46.0%) who fulfilled two versus 322 (52.4%) who fulfilled one versus 73 (64.0%) who fulfilled no criteria. After IPTW adjustment addressing all 2078 PC patients, 5 year CSM rates were 69.7% with PLND versus 64.2% without PLND (multivariable hazard ratio [mHR], 0.65; 95% confidence interval [CI], 0.54-0.77; p < 0.001). Conversely, for the 492 patients who fulfilled all three PC criteria, the 5 year CSM rates were 83.2% versus 81.8% (mHR, 0.76; 95% CI, 0.46-1.26, p = 0.3). Finally, for the 1586 patients who did not fulfill all three criteria, the 5 year CSM rates were 66.6% versus 58.0% (mHR, 0.69; 95% CI, 0.57-0.84; p < 0.001).
conclusionOnly a small minority of PC patients met all three eligibility criteria, exhibiting the most favorable survival. For those individuals, PLND had no effect on CSM. Conversely, for the majority of PC patients who did not fulfill all three criteria, PLND independently predicted significantly lower CSM.
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Registered trials
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