Evidence map›Paper›PMID 41339649›Full record

ArticleScientific reports2025

Combined in vitro and computational studies on the antioxidant and anticancer effects of Caesalpinia digyna (Rottl.) fruit extracts.

Kaniz Fatema, Md Anamul Haque, Jinat Fatema Sharna, Md Abdul Majed Patwary, Md Najem Uddin, Mohsin Kazi, Ashok Kumar, Nellore Bhanu Chandar, Chang-Guo Zhan

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaniz FatemaDepartment of Pharmacy, Comilla University, Cumilla, 3506, Bangladesh.
Md Anamul HaqueDepartment of Pharmacy, Comilla University, Cumilla, 3506, Bangladesh. anamul@cou.ac.bd.
Jinat Fatema SharnaDepartment of Pharmacy, Comilla University, Cumilla, 3506, Bangladesh.
Md Abdul Majed PatwaryDepartment of Chemistry, Comilla University, Cumilla, 3506, Bangladesh.
Md Najem UddinBangladesh Council of Scientific and Industrial Research, Dhaka, Bangladesh.
Mohsin KaziKayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 1145, Kingdom of Saudi Arabia.
Ashok KumarVitiligo Research Chair, Department of Dermatology, College of Medicine, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia.
Nellore Bhanu ChandarDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA.
Chang-Guo ZhanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. zhan@uky.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caesalpinia digyna Rottl. is an evergreen shrub traditionally used as an astringent, phthisis, antipyretic, nervine tonic, and diabetes remedy. The goal is to determine the fruit extract's antioxidant, anticancer, and cytotoxic effects through in vitro and computational studies. First, the methanol extract was prepared, and fractionation was performed using petroleum ether, dichloromethane, ethyl acetate, and distilled water. Preliminary screening was done using qualitative techniques, while Folin-Ciocalteu and AlCl

Indexed as

Antineoplastic Agents, PhytogenicAntioxidantsCaesalpiniaPhytochemicalsPlant ExtractsA549 CellsAnimalsCell SurvivalChlorocebus aethiopsDrug Screening Assays, AntitumorFlavonoidsFruitHumansMCF-7 CellsMolecular Docking SimulationMolecular Dynamics SimulationAntineoplastic Agents, PhytogenicAntioxidantsFlavonoidsPhenolsPhytochemicalsPlant Extracts1,3-Dihydroxyanthraquinone (C14)ADMETAnticancerCaesalpinia digynaGC–MS profilingMolecular dockingMolecular dynamics simulation

Identifiers

PMID41339649
PMCPMC12764594

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.