Evidence map›Paper›PMID 41339752›Full record

ArticleOncogene2026

Unveiling EMC6 as a novel pathogenic determinant in hepatocellular carcinoma: orchestration of lipid metabolism through regulation of lipid droplet-associated enzyme HSD17B13.

Yun Zhang, Chanyu Xiong, Zhilin Jiang, Xiao Wang, Zihao Wang, Junyao Chen, Qiong Li, Yangyang Luo, Xudan Yang, Chen Chu and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yun Zhang *Genetic Diseases Key Laboratory of Sichuan Province, Medical Genetics and Rare Diseases Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.ORCID http://orcid.org/0009-0001-7987-4944
Chanyu Xiong *Genetic Diseases Key Laboratory of Sichuan Province, Medical Genetics and Rare Diseases Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Zhilin Jiang *Genetic Diseases Key Laboratory of Sichuan Province, Medical Genetics and Rare Diseases Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xiao WangGenetic Diseases Key Laboratory of Sichuan Province, Medical Genetics and Rare Diseases Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Zihao WangGenetic Diseases Key Laboratory of Sichuan Province, Medical Genetics and Rare Diseases Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Junyao ChenGenetic Diseases Key Laboratory of Sichuan Province, Medical Genetics and Rare Diseases Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Qiong LiGenetic Diseases Key Laboratory of Sichuan Province, Medical Genetics and Rare Diseases Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yangyang LuoGenetic Diseases Key Laboratory of Sichuan Province, Medical Genetics and Rare Diseases Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xudan YangDepartment of Pathology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Chen ChuDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8084-0867
Shikai ZhuOrgan Transplant Center, Sichuan Provincial Key Laboratory for Clinical Immunology Translational Medicine, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. zhushikai@uestc.edu.cn.ORCID http://orcid.org/0009-0007-9478-932X
Xianjun ZhuGenetic Diseases Key Laboratory of Sichuan Province, Medical Genetics and Rare Diseases Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. xjzhu2@126.com.ORCID http://orcid.org/0000-0002-2531-7552
Yu ZhouGenetic Diseases Key Laboratory of Sichuan Province, Medical Genetics and Rare Diseases Center, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. zhouyu422@yahoo.com.ORCID http://orcid.org/0000-0003-1216-9893

Funding

Department of Science and Technology of Sichuan Province (Sichuan Provincial Department of Science and Technology) 22JCQN0028National Natural Science Foundation of China (National Science Foundation of China) 81970825
6 · The paper itself

Abstract

The endoplasmic reticulum (ER) membrane protein complex (EMC) is an ER multiprotein complex that affects a wide range of pathophysiological processes. Recently, the function of EMC6, a subunit of EMC, has been attracting attention for its role in cancers. However, research on EMC6 in the context of hepatocellular carcinoma (HCC) remains unknown. Here, we first observed the decreased EMC6 expression in human HCC tissues, and diminished expression level of EMC6 was associated with poor prognosis of HCC patients. In parallel, the knockdown of EMC6 promoted tumor progression both in HCC cell lines and in tumor-cell bearing nude mice. To delineate the in vivo roles of EMC6, we generated a hepatocyte-specific knockout of Emc6 (Emc6

Indexed as

17-Hydroxysteroid DehydrogenasesCarcinoma, HepatocellularLipid DropletsLipid MetabolismLiver NeoplasmsMembrane ProteinsAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMaleMiceMice, KnockoutMice, Nude17-Hydroxysteroid DehydrogenasesHSD17B13 protein, humanMembrane Proteins

Identifiers

PMID41339752

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.