ReviewNature reviews. Gastroenterology & hepatology2026
Mechanisms of chronic abdominal pain in inflammatory bowel disease and implications for treatment.
Review in Nature reviews. Gastroenterology & hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- DSS Colitis Model: Traps, Tricks, and Reporting Recommendations.Biomedicines · 2026Review
- Commentary: SEMA3B is associated with disease activity and infliximab response in IBD patients but does not contribute to the development of intestinal inflammationFrontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic abdominal pain is prevalent among individuals with inflammatory bowel disease (IBD). Substantial progress has been made in the past few decades in understanding how pain signals travel from the gut to the brain. Preclinical studies have greatly contributed to uncovering the mechanisms of chronic pain in IBD. However, practical applications in clinical settings are still lacking. In this Review, we present the current understanding of the pathological mechanisms of chronic pain in IBD. We explore the neuroplastic changes that occur along the afferent pain pathway from the nerve endings in the colonic mucosa to the brain. We explore the importance of new variables in chronic IBD pain, including the influence of host-microbe interactions during disease, and the effect of comorbid psychological factors, including stress and anxiety, in triggering pain. Finally, we discuss gaps in treatment strategies while proposing new directions for research to identify novel priorities that could pave the way for effective pain therapies.
Indexed as
Identifiers
41339763What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.