Evidence mapPaperPMID 41339771Full record

ArticlePediatric research2025

A non-invasive tool for the early identification of children at risk of cardiometabolic dysfunction: data from the PODiaCar project.

Valeria Calcaterra, Lucia Labati, Cristina Campoy, Virginia Rossi, Giulia Fiore, Mireia Escudero-Marin, Matteo Vandoni, Elvira Verduci, Luca Marin, Valter Pagani and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Valeria CalcaterraDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. valeria.calcaterra@unipv.it.ORCID http://orcid.org/0000-0002-2137-5974
Lucia LabatiPediatric Department, Buzzi Children's Hospital, Milano, Italy.
Cristina CampoyDepartment of Paediatrics, University of Granada, Granada, Spain.
Virginia RossiPediatric Department, Buzzi Children's Hospital, Milano, Italy.
Giulia FiorePediatric Department, Buzzi Children's Hospital, Milano, Italy.
Mireia Escudero-MarinDepartment of Paediatrics, University of Granada, Granada, Spain.
Matteo VandoniLaboratory of Adapted Motor Activity (LAMA), Department of Public Health, Experimental Medicine and Forensic Science, University of Pavia, Pavia, Italy.
Elvira VerduciPediatric Department, Buzzi Children's Hospital, Milano, Italy.
Luca MarinLaboratory of Adapted Motor Activity (LAMA), Department of Public Health, Experimental Medicine and Forensic Science, University of Pavia, Pavia, Italy.
Valter PaganiGrant & Research Department-LJA-2021, Asomi College of Sciences, Marsa, Malta.
Camilo CorbelliniDepartment of Physiotherapy, LUNEX International University of Health, Exercise and Sports, Differdange, Luxembourg.
Savina MannarinoPediatric Cardiology Buzzi Children's Hospital, Milano, Italy.
Rocio Bonillo LeonDepartment of Paediatrics, University of Granada, Granada, Spain.
Inmaculada GuerreroDepartment of Paediatrics, University of Granada, Granada, Spain.
Vittoria Carnevale PellinoLaboratory of Adapted Motor Activity (LAMA), Department of Public Health, Experimental Medicine and Forensic Science, University of Pavia, Pavia, Italy.
Alessandro GattiLaboratory of Adapted Motor Activity (LAMA), Department of Public Health, Experimental Medicine and Forensic Science, University of Pavia, Pavia, Italy.
Umberto CirielloDepartment of Health Sciences, University of Milano, Milano, Italy.
Gianvincenzo ZuccottiPediatric Department, Buzzi Children's Hospital, Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly identification of children at risk for metabolic syndrome (MetS) can reveal traits linked to cardiometabolic disease. We aimed to develop a simple, user-friendly tool to detect pediatric cardiometabolic risk using clinical, nutritional, and lifestyle data.

methodsA total of 317 patients (11.35 ± 3.62) were assessed using clinical, dietary, and biochemical data. Metabolic risk was defined by a MetS z-score >0.75, and MetS diagnosis required at least three altered parameters (body composition, blood pressure, glucose, lipids). A 22-variable binary tool generated a cumulative risk score: ≥7 altered components indicated high risk; otherwise, low risk.

resultsA pathological MetS-score was found in 62.15% of subjects, while MetS was diagnosed in 39.4%. The MetS z-score was significantly correlated with MetS prevalence (r = 0.581). When considering a screening tool score ≥7, along with patients presenting at least 3 of 4 altered MetS parameters, the results demonstrated good sensitivity (0.768 [0.715, 0.835]), negative predictive value (0.775 [0.702, 0.848]), and accuracy (0.618 [0.564, 0.672]), though specificity (52.1% [0.420, 0.600]) and positive predictive value (0.511 [0.439, 0.582]) were moderate.

conclusionA score ≥7 reliably identifies children at cardiometabolic risk, providing a sensitive, non-invasive tool that supports early detection, prevention, and personalized care while reducing time and healthcare costs. IMPACT: Early detection of at-risk children can uncover cardio-metabolic traits. A 22-noninvasive variable tool was developed to identify pediatric cardio-metabolic risk. A score ≥7 effectively identifies children at cardiometabolic risk. The proposed non-invasive tool achieves good sensitivity (76.8%) and moderate specificity (52.1%). The tool supports clinicians in prevention, monitoring, and personalized care.

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.