Evidence map›Paper›PMID 41340042›Full record

ArticleBMC pediatrics2025

Study protocol for a randomized clinical trial to reduce weight among youth with obesity using time-restricted eating: the TRECO study.

Xiaoyan Shi, Peien Jiang, Penghao Wang, Xingwei Guo, Mengxuan Ye, Zhiying Jiang, Yan Chen, Tingjuan Fan, Guanghui Mao, Chang Zhou and 5 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06583447 (Time Restricted Eating in Childhood Obesity), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06583447 narecruitingnot on this map

Time Restricted Eating in Childhood Obesity: An Open-Label, Blinded-Endpoint, Parallel-Controlled, Randomized Clinical Trial

TypeinterventionalSponsorXiaoyan ShiRan2024 to 2027Enrolled128ConditionsChildhood ObesityArmsCalorie-restricted diet (CRD), Time-restricted eating (TRE)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiaoyan Shi *Children's Health Management Center, Children's Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.
Peien Jiang *Department of Epidemiology, School of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, China.
Penghao Wang *Department of Epidemiology, School of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, China.
Xingwei GuoDepartment of Epidemiology, School of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, China.
Mengxuan YeDepartment of Children Health Care, Children's Hospital of Soochow University, Suzhou, China.
Zhiying JiangDepartment of Children Health Care, Children's Hospital of Soochow University, Suzhou, China.
Yan ChenDepartment of Children Health Care, Children's Hospital of Soochow University, Suzhou, China.
Tingjuan FanChildren's Health Management Center, Children's Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.
Guanghui MaoChildren's Health Management Center, Children's Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.
Chang ZhouDepartment of Epidemiology, School of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, China.
Lu ZhaoDepartment of Children Health Care, Children's Hospital of Soochow University, Suzhou, China.
Mingzhi ZhangDepartment of Epidemiology, School of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, China.
Lei WuDepartment of Maternal and Child Health, Suzhou Industrial Park Center for Disease Control and Prevention, Suzhou, China.
Jian WangPediatric Research Institute of Soochow University, Children's Hospital of Soochow University, Suzhou, China. wj196312@vip.163.com.
Hao PengDepartment of Epidemiology, School of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, China. penghao@suda.edu.cn.

Funding

Children's Nutrition and Related Disease Research Funding Project of Jiangsu Nutrition Society JYXE202302National Natural Science Foundation of China 82173596Suzhou Municipal Science and Technology Bureau SKY2023036Suzhou Municipal Science and Technology Bureau SKY2023041Suzhou Municipal Science and Technology Bureau SYW2025048
6 · The paper itself

Abstract

backgroundChildhood obesity is a major metabolic disorder affecting approximately 20% of children and adolescents. Because around 80% of obese adolescents will still be obese in adulthood, action to reduce obesity in children and adolescents is needed. Although a caloric-restricted diet (CRD) is the primary treatment for obesity, adherence to CRD typically declines over time, and many individuals who lose weight with this strategy regain it. Accumulating evidence suggests that time-restricted eating (TRE) has a significant impact on weight loss in adults with obesity. However, the weight-loss effect of TRE on childhood obesity remains largely lacking in trial evidence, due to the significant differences in metabolic states and eating behavior plasticity between children and adults.

methodsWe will conduct an open-label, blinded-endpoint, parallel design, randomized controlled trial to assess the efficacy of 12-hour TRE on weight loss in children with obesity compared to CRD. A total of 128 patients with childhood obesity (8–17 years old, BMI-Z value > 2) will be enrolled and allocated into two arms by block randomization stratified by sex and age. Standardized lifestyle counseling will be provided for all participants to enhance physical activity and healthy eating habits. Based on the standardized lifestyle counseling, 12-hour TRE and CRD will be administered to the experimental and control groups, respectively. The short-term effect will be evaluated after 12 weeks of intervention by comparing the magnitude of BMI-Z reduction from baseline between the two groups. The intervention will be extended to 48 weeks to test the long-term effect and adherence. DISCUSSION: In the TRE program, participants only need to consider the timing of meals and the duration of fasting. Available evidence suggests that the earlier dinner ends, the better, but the duration of fasting is not as long as it should be, and the longer it is, the worse compliance may be. Although several trials have been conducted to examine the weight loss effects of 14- and 16-hour TRE in childhood obesity, no study has been designed regarding 12-hour TRE, while 12-hour fasting is relatively more acceptable in children.

trial registrationClinicalTrials.gov ID: NCT06583447. Registered 29 August 2024. https://clinicaltrials.gov/study/NCT06583447 .

Indexed as

Intermittent FastingPediatric ObesityWeight LossAdolescentCaloric RestrictionChildFemaleHumansMaleRandomized Controlled Trials as TopicCalorie-restricted dietChildhood obesityRandomized clinical trialTime-restricted eating

Identifiers

PMID41340042
PMCPMC12781309

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.