SynthesisEuropean journal of medical research2025
Mitochondrial dynamics and function in neural differentiation: a systematic review.
Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Mitochondrial regulation of brain development: evidence from zebrafish models.Fish physiology and biochemistry · 2026Review
- Integration of Metabolic Pathways and Micronutrient Signals Influences Neurodevelopment by Modulating Neural Stem Cell Dynamics.Molecular neurobiology · 2026Review
- Perfluorooctanoic acid (PFOA) induces lipid accumulation, oxidative stress, and reduced neurogenesis in primary human neuronal progenitor cells.Frontiers in toxicology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMitochondrial function has emerged as a critical regulator of neural differentiation, yet a comprehensive understanding of its diverse roles and temporal dynamics remains elusive. This systematic review synthesizes current evidence regarding mitochondrial contributions to neural stem cell differentiation and their implications for neurodevelopmental disorders.
methodsA systematic search was conducted across PubMed, Web of Science, and Scopus databases from inception to January 2025. Studies investigating mitochondrial properties during neural differentiation were included. Data extraction focused on temporal changes in mitochondrial function, molecular mechanisms, and pathological implications. Quality assessment was performed using modified SYRCLE criteria.
resultsAnalysis of 50 studies revealed distinct temporal patterns of mitochondrial regulation during neural differentiation. Early stages (days 0-3) showed predominant mitochondrial fragmentation and elevated ROS levels, while intermediate stages (days 4-7) demonstrated a shift toward oxidative phosphorylation with increased fusion events. Late-stage differentiation (beyond day 7) exhibited mature mitochondrial networks and stable bioenergetic profiles. The key molecular mechanisms included calcium signaling, Wnt/β-catenin pathway activation, and dynamic regulation of fusion/fission proteins. Mitochondrial dysfunction was consistently associated with impaired neural differentiation across multiple neurodevelopmental disorders.
conclusionsMitochondrial regulation of neural differentiation involves stage-specific changes in morphology, metabolism, and signaling functions. The identification of key molecular pathways provides promising therapeutic targets for neurodevelopmental disorders. Future research should focus on standardizing assessment methods, understanding tissue-specific regulation, and developing targeted interventions for clinical applications. These findings highlight the therapeutic potential of mitochondrial-targeted approaches in treating neurodevelopmental disorders and advancing regenerative medicine strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.