ArticleBMC genomic data2025
Effects ofexosome miRNA-369-3p on the biological behavior of trophoblast cells in gestational diabetes.
Article in BMC genomic data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
aimThe purpose of this study was to discuss effects of exosome miRNA-369-3p on the biological behavior of trophoblast cells in gestational diabetes. MATERIALS AND
methodsMeasuring miRNA-369-3p mRNA expression in Normal and GDM pregnant women by RT-qPCR assay; using high glucose to make GDM cell model; using CCK-8 and flow cytometry to evaluate cell proliferation andapoptosis; measuring cell invasion and migration by transwell and wound healing assay; IL-10 mRNA and protein expression by RT-qPCR and WB assay; correlation between miRNA-369-3p and IL-10 by Dual luciferase assay.
resultsCompared with normal pregnant women, miRNA-369-3p mRNA level significantly up-regulation in GDM pregnant women (P<0.001); with high glucose stimulating, compared with Normal group, the cell proliferation rate (78.30 ± 4.27%) significantly inhibited with cell apoptosis significantly increasing (24.55 ± 2.01%) (P<0.001), cell invasion (65.33 ± 3.65%) and migration (48.31 ± 4.18) activities significantly inhibited with IL-10 significantly down-regulation (P<0.001, respectively). With miRNA-369-3p inhibitor supplement, the cell activities were significantly improved with IL-10 increasing.
conclusionExosome miRNA-369-3pknockdown had effects to improved high glucose induced HTR-8/Svneo cell biological activities by stimulating IL-10.
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