Evidence map›Paper›PMID 41340210›Full record

ArticleThoracic research and practice2025

A NAMs-Based Microphysiological System for Metastasis and Mechanobiology Studies.

Basar Dogan, Pelin Saglam-Metiner, Tuncay Goksel, Ozlem Yesil-Celiktas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Basar DoganDepartment of Bioengineering, Ege University Faculty of Engineering, İzmir, Türkiye.
Pelin Saglam-MetinerDepartment of Bioengineering, Ege University Faculty of Engineering, İzmir, Türkiye.
Tuncay GokselTranslational Pulmonary Research Center (EgeSAM), Ege University, İzmir, Türkiye.
Ozlem Yesil-CeliktasDepartment of Bioengineering, Ege University Faculty of Engineering, İzmir, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLung and breast cancers are among the most common types of cancer worldwide, with approximately 2.5 million new cases occurring each year. MATERIAL AND

methodsLung cancer metastasis-on-a-chip platform consists of two PDMS layers, where two tissue chambers represent the lung and bone compartments, and a single microchannel serve as the vascular lumen. The dual-chamber microfluidic system integrates lung cancer epithelial and stromal cells in one compartment and human osteoblasts encapsulated in gelatin methacrylate hydrogel in the other, enabling dynamic study of EMT and cancer cell migration. Time-lapse fluorescence microscopy was employed to visualize real-time cellular dynamics and migration events. ELISA was used to quantify secreted EMT-related proteins, while quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to assess gene expression changes associated with metastatic progression. RESULTS AND

conclusionMicroscopic observations demonstrated that lung cancer cells successfully metastasize to bone stroma and disrupt the bone microenvironment, like the

Indexed as

cell migrationEpithelial-mesenchymal transitionexposomelung cancermechanobiologyNAMs

Identifiers

PMID41340210
PMCPMC12673185

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.