Evidence map›Paper›PMID 41340290›Full record

ArticleAdvanced healthcare materials2026

Co-Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap.

Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J Horn and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sarah JonesDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID https://orcid.org/0000-0002-9539-545X
Madeline LaudeDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID https://orcid.org/0009-0001-4474-8833
Zeenat OyebanjiDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Ruchi BirurDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID https://orcid.org/0009-0008-0778-4211
Andres Luengo MartinezDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID https://orcid.org/0009-0003-7084-484X
Isabelle GilbertDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID https://orcid.org/0009-0005-5543-808X
Phillip BaekDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Nichole LongbottomDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Nicole McCulloughDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Staci J HornDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Chien-Yu LinDepartment of Aerospace Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Matthew J LohrDepartment of Aerospace Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Fred ClubbDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Manuel K RauschDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Elizabeth Cosgriff-HernandezDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID https://orcid.org/0000-0002-4701-5600

Funding

National Science Foundation Graduate Research Fellowship Program 2020300397
6 · The paper itself

Abstract

Decellularized tissue possesses significant regenerative potential, yet fabricating complex extracellular matrix (ECM) scaffolds remains challenging. Blending with synthetic polymers aids ECM fabrication but often relies on digested ECM, and encapsulation within the synthetic matrix can limit cell-ECM interactions. We recently developed a suspension electrospinning platform to facilitate ECM fabrication without digestion or polymer-carriers. Its integration into a co-electrospinning system enables modular design of composite scaffolds, combining ECM's regenerative potential with the advantages of synthetic polymers. This study compares co-electrospinning and blend electrospinning of polycaprolactone and small intestinal submucosa (SIS) for use as a bone wrap to augment membrane durability, sustain infection control, and enhance vascularity in Masquelet's induced membrane technique. Co-spun wraps improve handling properties compared to ECM wraps; solvent welding is used to achieve target suture retention standards without diminishing SIS content. Unlike blended wraps, co-spun wraps support full-thickness cell infiltration within 4 weeks, release gentamicin at bactericidal concentrations for 6 weeks, and demonstrate angiogenic properties. Co-spun wraps achieve full tissue integration and enhanced membrane vascularity in an in vivo subcutaneous rat model for 6 weeks. These findings highlight the functionality of a co-electrospinning modular design and the efficacy of using a co-spun wrap in bone tissue engineering applications.

Indexed as

Bone and BonesExtracellular MatrixPolyestersTissue EngineeringTissue ScaffoldsAnimalsHumansIntestinal MucosaRatspolycaprolactonePolyestersangiogenesisantibioticselectrospinningfiber‐reinforcementMasquelet Technique

Identifiers

PMID41340290
PMCPMC13378472

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.