Unified Total Synthesis of Phrymarolin and Haedoxan Natural Products.

Jan Paciorek, Antoine D F Guy, Alexander Sudau, David M Barber, Thomas Magauer

Abstract read

In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jan PaciorekDepartment of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.

Antoine D F GuyDepartment of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.

Alexander SudauResearch and Development, Profile Driven Chemistry, Bayer AG, Crop Science Division, Alfred Nobel Str. 50, 40789 Monheim am Rhein, Germany.

David M BarberResearch and Development, Profile Driven Chemistry, Bayer AG, Crop Science Division, Industriepark Höchst, 65926 Frankfurt am Main, Germany.ORCID 0000-0001-9906-1695

Thomas MagauerDepartment of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.ORCID 0000-0003-1290-9556

Funding

European Research Council 101000060

6 · The paper itself

Abstract

We disclose a unified synthetic route to the furofuran lignans phrymarolin I and II as well as the insecticidal natural products haedoxan A and D. The furofuran core was constructed using a formal [3 + 2] cycloaddition between an α-silyloxy aldehyde and a styrene, followed by a samarium(II) iodide promoted-cyclization of a β-formyloxy ketone. While this sequence enabled the synthesis of phrymarolin I and II in eight steps, attempts to unmask the

Indexed as

Biological ProductsInsecticidesLignansCyclizationCycloaddition ReactionMolecular StructureBiological ProductsInsecticidesLignans

Identifiers

PMID41340551

DOI10.1021/jacs.5c16676

PMCPMC7618468

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.