Trial reportFrontiers in nutrition2025
Effects of olive leaf extract supplementation on systemic markers of tissue aging and remodeling in postmenopausal women: a randomized controlled trial with exploratory skin outcomes.
Trial report in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05744453 (The Effect of 12-week Supplementation With Olive Leaf Extract), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of 12-week Supplementation With Olive Leaf Extract (OLE) on Body Composition and Muscle Strength, Skin-aging and Menopause-related Quality of Life in Postmenopausal Women (45-70 y); a Randomized Controlled Trial
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Menopause marks the end of a woman's reproductive cycle and is associated with a decline in estrogen levels. This hormonal shift accelerates systemic aging processes, affecting metabolic regulation, cardiovascular risk, and connective tissue integrity. Circulating biomarkers offer a non-invasive way to monitor these changes. Objectives: This randomized, double-blind, placebo-controlled study aimed to determine the effects of 12 weeks of olive leaf extract (OLE) supplementation on systemic markers of tissue aging and remodeling in postmenopausal women (45-70 years), and explored skin quality in a subgroup. Methods: Sixty-five healthy postmenopausal women received 250 mg OLE or placebo daily. Circulating levels of elastin, collagen, hydroxyproline, matrix metalloproteinase-2 (MMP-2), advanced glycation end-products, and fasting glucose were measured. In a subgroup ( Results: Elastin levels significantly increased in the placebo group while they remained stable in the OLE group [-6.3 [-12.0; -0.05], Conclusion: The exploratory skin analyses revealed a reduction in pore number and surface skewness, suggesting that OLE may exert localized effects on skin structure. Although no statistically significant effects on systemic markers associated with tissue aging and remodeling were observed, the trends suggest potential modulation of pathways involved in extracellular matrix preservation and protein glycation. These findings warrant further investigation into both systemic and dermal effects of OLE in the context of postmenopausal aging. Clinical trial registration: The study was registered online at ClinicalTrials.gov as NCT05744453 and was conducted at Maastricht University.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.