SynthesisFrontiers in nutrition2025
Impact of nutritional support on mortality among critically ill patients with different nutritional risks: a systematic review with meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To identify appropriate nutritional support strategies for critically ill patients with different levels of nutritional risk. Methods: A systematic search of PubMed, MEDLINE, Cochrane Library, and Embase was conducted from database inception to 19 May 2025, which included critically ill patients classified into high risk (5-9) and low risk (0-4) groups based on the modified Nutrition Risk in the Critically Ill (mNUTRIC) score. Data on study characteristics, patient demographics, and nutritional support details were extracted. The primary outcome was all-cause mortality following nutritional support stratified by nutritional risk among critically ill patients. A meta-regression analysis was performed to assess the influence of covariates on effect sizes and to identify potential sources of heterogeneity. Trial sequential analysis (TSA) was conducted to evaluate the robustness and reliability of the pooled effect estimates. Results: Eleven eligible trials, comprising a total of 7,442 participants, were included in this systematic review. The meta-analysis demonstrated that high nutritional risk was significantly associated with increased mortality (OR: 2.26, 95% CI: 1.80-2.83, Conclusion: The mNUTRIC score is a validated prognostic tool in critically ill patients, but its effectiveness in guiding energy support remains limited. Systematic Review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42020188064, Identifier: CRD42020188064.
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