ArticleJournal of contemporary brachytherapy2025
Prospective trial on focal treatment with hemigland brachytherapy in low-risk prostate cancer: A negative study.
Article in Journal of contemporary brachytherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
15 authors.
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Abstract
Purpose: To determine whether hemi-gland seed brachytherapy (HGBT) is as effective as whole-gland seed brachytherapy (WGBT) in patients with single-lobe, low-risk and favorable intermediate-risk prostate cancer (PCa). Material and methods: Phase II clinical trial in patients with low- and favorable intermediate-risk PCa with HGBT. Enrolment took place between 2016 and 2020. All patients ( Results: The mean age was 64.9 years (range, 50-78), the mean baseline prostate-specific antigen (PSA) was 6.12 ng/ml (range, 1.53-10), and the mean nadir was 1.4 ng/ml (range, 0.17-4.24). Most patients (37/38) had Gleason 3 + 3. The mean follow-up was 71.4 months (range, 44-93). Seventeen patients developed biochemical relapse, and 14 presented local clinical progression (contralateral, Conclusions: In this trial, patients treated with hemi-gland brachytherapy had significantly higher biochemical failure and contralateral relapse rates than a historical cohort of patients treated with WGBT. Larger, well-designed clinical trials are needed to better assess the efficacy of HGBT in the treatment of low-risk PCa.
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