Evidence map›Paper›PMID 41340891›Full record

ArticleComputational and structural biotechnology journal2025

M-Ras distinct activation scenarios: A mechanistic outlook and targeting.

Liang Xu, Yonglan Liu, Hyunbum Jang, Ruth Nussinov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. How Functional Variants Reconfigure the Rac2 Conformational Landscape.bioRxiv : the preprint server for biology · 2026
    Article
  3. D81 Mutants Reveal Hidden EF-Tu Diversity while Natural Sequences Preserve Aspartate.Computational and structural biotechnology journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Liang XuComputational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Yonglan LiuCancer Innovation Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Hyunbum JangComputational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Ruth NussinovComputational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The conformational states of canonical Ras (H-, K-, and N-Ras) GTPases define their nucleotide-exchange and effector binding capabilities. M-Ras, whose mutational variants can cause cancer directly, and indirectly through their complexes, appear to be one exception. Unlike canonical Ras, the GTP-bound M-Ras is mostly in the

Indexed as

Conformational ensembleGTPasesInhibitorM-RasMutationRASopathy

Identifiers

PMID41340891
PMCPMC12670535

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.