Evidence map›Paper›PMID 41341098›Full record

ReviewFrontiers in bioengineering and biotechnology2025

Comparative analysis of dental-derived stem cells and alternative stem cell sources: properties and regenerative functions.

Kexin Yang, Shengmeng Yuan, Yuhao Wang, An Lin, Fangjun Huo, Zhaorui Jin, Chao Yang, Weidong Tian

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kexin YangDepartment of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan university Chengdu, Chengdu, Sichuan, China.
Shengmeng YuanDepartment of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan university Chengdu, Chengdu, Sichuan, China.
Yuhao WangDepartment of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan university Chengdu, Chengdu, Sichuan, China.
An LinDepartment of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan university Chengdu, Chengdu, Sichuan, China.
Fangjun HuoDepartment of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan university Chengdu, Chengdu, Sichuan, China.
Zhaorui JinDepartment of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan university Chengdu, Chengdu, Sichuan, China.
Chao YangChengdu Shiliankangjian Biotechnology Co., Ltd., Chengdu, Sichuan, China.
Weidong TianDepartment of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan university Chengdu, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to their accessibility, wide range of sources and unique biological characteristics, dental stem cells have broad application prospects in regenerative medicine. This cell population mainly includes dental pulp stem cells, periodontal ligament stem cells, stem cells from deciduous teeth, and dental follicle stem cells. In addition, dental stem cells have good microenvironment-specific immunomodulatory functions, including inhibiting T cell activation, promoting the polarization of regulatory T cells and regulating the phenotype of macrophages, thereby promoting tissue repair and reducing inflammation. These advantages are complemented by its strong osteogenic differentiation ability, providing a new strategy for oral tissue regeneration, and providing broad prospects for the treatment of nervous system related diseases due to its ectodermal homology with neural crest. This review systematically summarizes the major advantages of dental stem cells in the field of regenerative medicine, outlines current progress in clinical translation, and discusses future research directions, while critically comparing their therapeutic potential and challenges with other mesenchymal stem cells sources to guide seed cell selection and clinical applications.

Indexed as

cell therapydental stem cellsmesenchymal stem cellsregenerative medicinetissue regeneration

Identifiers

PMID41341098
PMCPMC12669115

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.