ArticleThe Lancet regional health. Western Pacific2025
Cardiometabolic health and risk of dementia and brain atrophy: a community-based prospective cohort study of 0.5 million adults in China.
Article in The Lancet regional health. Western Pacific, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Association between dietary patterns and CAIDE-predicted dementia risk: A 20-year cohort of the Korean Genome and Epidemiology study.GeroScience · 2026Article
- Marbling Matters: Lean and Fatty Red Meat Show Opposing Associations with Brain Structural Indices.Nutrients · 2026Article
- Interactions between rare variants in DNA repair genes and cardiometabolic risk explain more variability in cognitive function.GeroScience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cardiometabolic health has been associated with dementia risk but prospective evidence is limited in China where the burden of cardiometabolic disease and dementia are rising. We investigate the relevance of markers of cardiometabolic health for risk of dementia and brain atrophy. Methods: China Kadoorie Biobank is a prospective cohort study involving 512,724 adults aged 30-79 years, recruited in 2004-2008 from 10 diverse regions. During ∼12 years' follow-up, 1099 dementia and 1418 brain atrophy cases were recorded through linked death registries and health insurance databases. Cox regression yield adjusted hazard ratios (HRs) for incident dementia and brain atrophy associated with markers of cardiometabolic health. Findings: The incidence rate for dementia and brain atrophy was 19.0 and 25.4 per 100,000 person-years, respectively, higher at older ages, and among males. Prior hypertension (adjusted HR 1.21 [95% CI 1.05-1.39]), diabetes (1.36 [1.13-1.65]) and stroke (2.52 [2.14-2.96]) were associated with higher risks of dementia and brain atrophy (1.30 [1.15-1.47], 1.32 [1.12-1.55], 2.43 [2.12-2.78], respectively). Prior IHD was associated with brain atrophy (1.69 [1.47-1.95]), but not dementia (1.17 [0.97-1.41]). Interpretation: These findings provide evidence of the relevance of markers of cardiometabolic health for dementia among adults in China, highlighting the importance of preventative strategies for cardiometabolic diseases that may lead to benefits for brain health. Funding: Wellcome Trust, MRC, BHF, CR-UK, Kadoorie Charitable Foundation, Chinese MoST and NSFC.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.