ArticleAge and ageing2025
Traumatic brain injury and mortality in older adults with and without pre-injury dementia.
Article in Age and ageing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Surgical Versus Medical Management in Older Adults with Traumatic Brain Injury: A Systematic Review and Meta-analysis.Neurocritical care · 2026Article
- 6-Month Recovery after Mild Traumatic Brain Injury in Older Adults: A TRACK-GERI Study.medRxiv : the preprint server for health sciences · 2026Article
- The latest research progress of ligustilide in the prevention and treatment of central nervous system disorders.Frontiers in pharmacology · 2026Review
- Natural History and Clinical Associations of Plasma Interleukin-6 Levels in Traumatic Brain Injury.Neurotrauma reportsArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncidence of traumatic brain injury (TBI) is rising in older adults. Dementia is a common comorbidity and may worsen post-TBI outcomes, but its effects have not been studied.
objectiveTo compare all-cause mortality following TBI or non-TBI trauma (NTT) and quantify the impacts of age, deprivation and dementia.
designPopulation-based retrospective cohort study.
settingLinked primary and secondary care electronic health records from the Secure Anonymised Information Linkage Databank. SUBJECTS: Adult residents in Wales aged 18-100 with hospitalised TBI or NTT recorded between January 2000 and December 2022.
methodsCox proportional hazard models were used to estimate survival within 1, 6 and 12 months of hospitalised TBI/NTT in those with and without pre-injury dementia diagnosis. Groups were propensity-matched by age, sex and morbidities. Models were stratified by age, sex and deprivation.
resultsA total of 23 428 TBIs (n = 18 940) and 589 169 NTTs (n = 421 259) were identified. TBIs were associated with higher mortality than NTT at all timepoints. Older age was associated with higher mortality after TBI, with 16.9% 1-month mortality in patients aged 65-79, and 31% in patients aged 80-100. In TBI patients, 30-day mortality was significant irrespective of dementia. About 6- and 12-month mortality were higher in those with than without pre-injury dementia diagnosis.
conclusionsTBI is associated with higher all-cause mortality than NTT, particularly in older age. Among those with TBI, patients with pre-injury dementia had particularly high chronic mortality. There is an urgent need to understand the reasons for poor outcomes in older adult TBI populations, especially those with dementia.
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