Evidence map›Paper›PMID 41342828›Full record

ArticleJACC. Asia2026

Diabetes and ALDH2 Gene Polymorphism on Post-Ablation Atrial Fibrillation Recurrence.

Junyan Jin, Ningjing Qian, Ying Gao, Jiayi Liu, Delong Chen, Bingqi Wang, Muhua Luo, Yu Zhang, Jian Ye, Ruhong Jiang and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05524142 (Association Between ALDH2 Gene Polymorphism and Atrial Fibrillation), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05524142 unknown statusnot on this map

Association Between ALDH2 Gene Polymorphism and Atrial Fibrillation

TypeobservationalSponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2022 to 2024Enrolled200ConditionsAtrial Fibrillation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Junyan JinDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China.
Ningjing QianDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China.
Ying GaoDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China.
Jiayi LiuDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China.
Delong ChenDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China.
Bingqi WangDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China.
Muhua LuoDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China.
Yu ZhangDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China.
Jian YeDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China.
Ruhong JiangDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lijuan WangZhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jun JiangDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China. Electronic address: jiang-jun@zju.edu.cn.
Yaping WangDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China. Electronic address: yapingwang@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (T2DM) and mitochondrial aldehyde dehydrogenase 2 (ALDH2) gene polymorphism exhibit significant associations with atrial fibrillation (AF) prevalence.

objectivesThis study aimed to evaluate the combined risk of T2DM and ALDH2 gene polymorphism in AF recurrence after radiofrequency catheter ablation.

methodsThis prospective multicenter cohort study enrolled 324 patients undergoing their first successful ablation from 3 centers. Patients were stratified by T2DM status and ALDH2 genotype. The primary outcome was AF recurrence, defined as atrial arrhythmia lasting ≥30 seconds after a 3-month blanking period post-ablation, analyzed using Kaplan-Meier survival curves and multivariable Cox proportional hazards regression.

resultsAt a median follow-up of 12.00 months (Q1-Q3: 10.98-12.00 months), 86 patients experienced AF recurrence. The risk of recurrence was significantly higher in patients with T2DM (44.3%, n = 39 of 88; 95% CI: 32.9%-53.8%) than in those without (19.9%, n = 47 of 236; 95% CI: 14.7%-24.9%; P < 0.001). T2DM and ALDH2-variant patients experienced the highest cumulative incidence of AF recurrence after ablation (n = 24 of 43, 55.8%; 95% CI: 38.2%-68.4%; P < 0.001). Multivariable regression analysis showed that the combination of T2DM and ALDH2-variant were the most powerful independent predictor for AF recurrence at 1-year (adjusted HR: 4.20; 95% CI: 2.04-8.64; P < 0.001).

conclusionsT2DM and ALDH2-variant significantly increases AF recurrence after radiofrequency catheter ablation. The link between genetic predisposition and diabetic metabolism highlights the potential for combined risk stratification to identify high-risk T2DM with AF patients for targeted preventive strategies of recurrence after ablation (AAAF [Association Between ALDH2 Gene Polymorphism and Atrial Fibrillation]; NCT05524142).

Indexed as

aldehyde dehydrogenase 2atrial fibrillationgene polymorphismradiofrequency catheter ablationsrecurrencetype 2 diabetes mellitus

Identifiers

PMID41342828
PMCPMC12959278

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.