Evidence map›Paper›PMID 41342897›Full record

ArticleeLife2025

Ptbp1 is not required for retinal neurogenesis and cell fate specification.

Haley Appel, Rogger P Carmen-Orozco, Clayton P Santiago, Thanh Hoang, Seth Blackshaw

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Haley AppelSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Rogger P Carmen-OrozcoSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-2460-9270
Clayton P SantiagoSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0001-7191-668X
Thanh HoangDepartment of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, Ann Arbor, United States.ORCID https://orcid.org/0000-0002-7666-3842
Seth BlackshawDepartment of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-1338-8476

Funding

Identification of gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller gliaR01EY036173 · NEI · JOHNS HOPKINS UNIVERSITY · PI Seth Blackshaw · 2024 to 2026
$2.0M
NEI NIH HHS R01 EY036173NEI NIH HHS R01EY036173
6 · The paper itself

Abstract

The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes neurogenesis, recent genetic studies have failed to replicate glia-to-neuron conversion following

Indexed as

Heterogeneous-Nuclear RibonucleoproteinsNeurogenesisPolypyrimidine Tract-Binding ProteinRetinaAnimalsCell DifferentiationMiceHeterogeneous-Nuclear RibonucleoproteinsPolypyrimidine Tract-Binding ProteinPtbp1 protein, mousecell fate specificationconditional mutantdevelopmental biologymouseneurogenesisneuroscienceretinaRNA splicing

Identifiers

PMID41342897
PMCPMC12677894

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.