Evidence map›Paper›PMID 41342990›Full record

ReviewMolecular neurobiology2025

Extracellular Vesicles: a Promising Therapy for Treatment of Central Nervous System Ischemia Reperfusion Injury.

Limei Wang, Xinzhu Zhu, Peiwen Jia, Hong Ma, Fengshou Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Limei Wang *Department of Anesthesiology, the First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Xinzhu Zhu *Department of Anesthesiology, the First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Peiwen JiaDepartment of Anesthesiology, the First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Hong MaDepartment of Anesthesiology, the First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Fengshou ChenDepartment of Anesthesiology, the First Hospital of China Medical University, Shenyang, Liaoning Province, China. fschen@cmu.edu.cn.

Funding

National Natural Science Foundation of China 82371287
6 · The paper itself

Abstract

Central nervous system ischemia-reperfusion injury, including cerebral ischemia reperfusion injury (CIRI) and spinal cord ischemia reperfusion injury (SCIRI), poses significant challenges in neurology. This condition is characterized by severe tissue damage following the restoration of blood flow after an ischemic event. Current therapeutic strategies primarily focus on re-establishing perfusion but often fail to address the secondary injuries induced by reperfusion, underscoring the need for innovative treatment. Extracellular vesicles (EVs) facilitate intercellular communication by transferring proteins, lipids, and nucleic acids, thereby influencing cellular pathways. This review examines the potential of EVs as a promising therapeutic strategy for central nervous system I/R injury. Growing evidence suggests that EVs can mitigate pathological mechanisms in both CIRI and SCIRI. Preclinical studies demonstrate that EVs derived from stem cells, astrocytes, and immune cells have shown potential in reducing damage and promoting recovery. Despite encouraging preclinical outcomes, the clinical translation of EV-based therapies faces several challenges, including standardization of EV production, optimization of delivery methods, and comprehensive evaluation of their safety and efficacy. Future research should prioritize elucidating the molecular mechanisms of EV action, refining production and delivery systems, and conducting clinical trials to assess the long-term therapeutic effects.

Indexed as

Central Nervous SystemExtracellular VesiclesReperfusion InjuryAnimalsHumansCentral nervous system ischemia–reperfusion injuryCerebral ischemia reperfusion injuryExtracellular vesiclesSpinal cord ischemia reperfusion injury

Identifiers

PMID41342990

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.