Evidence map›Paper›PMID 41343115›Full record

ArticleRheumatology and therapy2026

Filgotinib Effectiveness in Rheumatoid Arthritis: Observational Analysis of a Large Multicenter Cohort.

Eleonora Celletti, Myriam Di Penta, Alarico Ariani, Simone Parisi, Romina Andracco, Bernd Raffeiner, Aurora Ianniello, Alberto Lo Gullo, Aldo Biagio Molica Colella, Marta Priora and 56 more

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Article in Rheumatology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

66 authors.

Eleonora CellettiRheumatology Unit, Clinica Medica Institute, Ospedale "SS. Annunziata" di Chieti/Università "G. d'Annunzio", Chieti, Italy.
Myriam Di PentaRheumatology Unit, Clinica Medica Institute, Ospedale "SS. Annunziata" di Chieti/Università "G. d'Annunzio", Chieti, Italy. myriamdipenta@gmail.com.ORCID http://orcid.org/0009-0008-0532-3366
Alarico ArianiInternal Medicine and Rheumatology Unit, University Hospital of Parma, Parma, Italy.
Simone ParisiRheumatology Department, Azienda Ospedaliera, Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Romina AndraccoInternal Medicine Unit, Rheumatology Outpatient Clinic, Imperia Hospital, Imperia, Italy.
Bernd RaffeinerDepartment of Rheumatology, Central Hospital of Bolzano (ASAA-SABES), Teaching Hospital of the Paracelsius Medical University, Bolzano, Italy.
Aurora IannielloRheumatology Outpatient Unit, ASL Novara, Novara, Italy.
Alberto Lo GulloRheumatology Unit, ARNAS Garibaldi di Catania, Catania, Italy.
Aldo Biagio Molica ColellaRheumatology Unit, Azienda Ospedaliera Papardo, Messina, Italy.
Marta PrioraRheumatology Day Hospital and Outpatient Clinic-ASL CN1, Cuneo, Italy.
Marino ParoliDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, Polo Pontino, Rome, Italy.
Federica LumettiRheumatology Unit, Azienda USL of Modena and University Hospital "Policlinico di Modena", Modena, Italy.
Viviana RavagnaniRheumatology Unit, Santa Chiara Hospital APSS, Trento, Italy.
Francesco GirelliRheumatology Unit, Ospedale GB Morgagni-L Pierantoni, Forlì, Italy.
Rosetta VitettaUnit of Rheumatology, ASL VC Ospedale S. Andrea, Vercelli, Italy.
Alessandro VolpeUnit of Rheumatology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.
Palma ScolieriDepartment of Medical Specialties, "Nuovo Regina Margherita" Hospital, Rome, Italy.
Alessandra BezziInternal Medicine and Rheumatology Unit, ASL Romagna Rimini, Rimini, Italy.
Francesca OmettoRheumatology Outpatient Clinic, Azienda ULSS 6 Euganea, Padua, Italy.
Elisa VisalliRheumatology Unit, Policlinico San Marco Hospital, Catania, Italy.
Antonella FarinaInternal Medicine Unit, Rheumatology Outpatient Clinic, Ospedale "A. Murri" di Fermo, Fermo, Italy.
Patrizia Del MedicoRheumatology Outpatient Clinic, Internal Medicine Unit, Civitanova Marche Hospital, Civitanova Marche, MC, Italy.
Elena BraviRheumatology Outpatient Clinic, Internal Medicine Unit, Rheumatology Unit, Ospedale G. Da Saliceto, Piacenza, Italy.
Matteo ColinaRheumatology Service, Section of Internal Medicine, Department of Medicine and Oncology, Ospedale Santa Maria Della Scaletta, Imola, Italy.
Maddalena LarosaDivision of Rheumatology, Department of Medical Specialties, Ospedale La Colletta-Azienda Sanitaria Locale 3 Genoa, Genoa, Italy.
Francesca SeraleRheumatology Day Hospital and Outpatient Clinic-ASL CN1, Cuneo, Italy.
Veronica FranchinaDirezione Medica, Azienda Ospedaliera Papardo, Messina, Italy.
Francesco Molica ColellaInternal Medicine Unit, Università Bicocca, Milan, Italy.
Giulio FerreroUnit of Diagnostic and Intervetional Radiology, Santa Corona Hospital, Pietra Ligure, Italy.
Gilda SandriRheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy.
Olga AddimandaRheumatology Unit, AUSL Bologna, Policlinico S. Orsola, AOU-IRCCS di Bologna, Bologna, Italy.
Massimo RetaRheumatology Unit, AUSL Bologna, Policlinico S. Orsola, AOU-IRCCS di Bologna, Bologna, Italy.
Fabio MascellaInternal Medicine and Rheumatology Unit, ASL Romagna Rimini, Rimini, Italy.
Maria Cristina FocheriniInternal Medicine and Rheumatology Unit, ASL Romagna Rimini, Rimini, Italy.
Alessia FiorenzaUnit of Rheumatology, ASL VC Ospedale S. Andrea, Vercelli, Italy.
Guido RoveraUnit of Rheumatology, ASL VC Ospedale S. Andrea, Vercelli, Italy.
Cecilia GiampietroRheumatology Outpatient Clinic, Azienda ULSS 6 Euganea, Padua, Italy.
Simone BernardiRheumatology Unit, Ospedale GB Morgagni-L Pierantoni, Forlì, Italy.
Natalia MansuetoInternal Medicine Unit, Rheumatology Outpatient Clinic, Imperia Hospital, Imperia, Italy.
Dario CamellinoDivision of Rheumatology, Department of Medical Specialties, Ospedale La Colletta-Azienda Sanitaria Locale 3 Genoa, Genoa, Italy.
Rosalba CaccavaleDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, Polo Pontino, Rome, Italy.
Valeria NuceraRheumatology Outpatient Unit, ASL Novara, Novara, Italy.
Emanuela SabatiniRheumatology Unit, Clinica Medica Institute, Ospedale "SS. Annunziata" di Chieti/Università "G. d'Annunzio", Chieti, Italy.
Pietro Del BiondoRheumatology Unit, Clinica Medica Institute, Ospedale "SS. Annunziata" di Chieti/Università "G. d'Annunzio", Chieti, Italy.
Maria Chiara DittoRheumatology Department, Azienda Ospedaliera, Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Ilaria PlatèRheumatology Outpatient Clinic, Internal Medicine Unit, Rheumatology Unit, Ospedale G. Da Saliceto, Piacenza, Italy.
Giuditta AdorniInternal Medicine and Rheumatology Unit, University Hospital of Parma, Parma, Italy.
Eleonora Di DonatoInternal Medicine and Rheumatology Unit, University Hospital of Parma, Parma, Italy.
Daniele SantilliInternal Medicine and Rheumatology Unit, University Hospital of Parma, Parma, Italy.
Gianluca LucchiniInternal Medicine and Rheumatology Unit, University Hospital of Parma, Parma, Italy.
Giorgio AmatoRheumatology Unit, Policlinico San Marco Hospital, Catania, Italy.
Francesco De LuciaRheumatology Unit, Policlinico San Marco Hospital, Catania, Italy.
Ylenia Dal BoscoRheumatology Unit, Policlinico San Marco Hospital, Catania, Italy.
Roberta FotiRheumatology Unit, Policlinico San Marco Hospital, Catania, Italy.
Gianluca SmerilliRheumatology Outpatient Clinic, Internal Medicine Unit, Civitanova Marche Hospital, Civitanova Marche, MC, Italy.
Gerolamo BianchiDivision of Rheumatology, Department of Medical Specialties, Ospedale La Colletta-Azienda Sanitaria Locale 3 Genoa, Genoa, Italy.
Rosario FotiRheumatology Unit, Policlinico San Marco Hospital, Catania, Italy.
Eugenio ArrigoniRheumatology Outpatient Clinic, Internal Medicine Unit, Rheumatology Unit, Ospedale G. Da Saliceto, Piacenza, Italy.
Antonio MarchettaUnit of Rheumatology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.
Riccardo BixioUnit of Rheumatology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.
Vincenzo BruzzeseDepartment of Medical Specialties, "Nuovo Regina Margherita" Hospital, Rome, Italy.
Enrico FusaroRheumatology Department, Azienda Ospedaliera, Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Dilia GiuggioliRheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy.
Carlo SalvaraniRheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy.
Francesco CipolloneRheumatology Unit, Clinica Medica Institute, Ospedale "SS. Annunziata" di Chieti/Università "G. d'Annunzio", Chieti, Italy.
Andrea BeccioliniInternal Medicine and Rheumatology Unit, University Hospital of Parma, Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe efficacy and safety of filgotinib (FIL) for the treatment of patients with rheumatoid arthritis (RA) have been evaluated in a number of randomized controlled trials. However, there is a scarcity of real-world studies evaluating the effectiveness, persistence, tolerability, and safety of FIL in everyday clinical practice. This study aimed to assess the effectiveness and retention rate of FIL in a real-world cohort of patients with RA.

methodsA multicenter retrospective cohort study of patients with RA treated with FIL was conducted in 27 Italian tertiary referral rheumatology centers. The drug retention rate (DRR) was estimated by the Kaplan-Meier method, while multivariate Cox regression was used to detect potential factors affecting drug survival and persistence in therapy. Disease activity score (DAS28-CRP) was assessed at baseline and after 6 and 12 months.

resultsWe enrolled 204 patients (80% female). The DRR of FIL was 90.2% (95% confidence interval (CI) 86-94.6%), 75.1% (95% CI 68.5-82.4%), and 64.7% (95% CI 56.3-74.3%) at months 6, 12, and 18, respectively. The DRR was negatively associated with the line of treatment and the presence of rheumatoid factor. Effectiveness was evaluated as DAS28-CRP response. At 6 months, DAS28-CRP remission was observed in 65 (36.1%) patients, and remission or low disease activity in 98 (54.4%). At 12 months, DAS28-CRP remission was observed in 64 (50.0%) patients, and remission or low disease activity in 81 (63.2%).

conclusionsThis analysis of real-world patients with RA demonstrated the effectiveness of FIL with a good DAS28-CRP response and high DRR at follow-up.

Indexed as

bDMARDcsDMARDDrug retention rateEffectivenessEfficacyFilgotinibJAK inhibitorRheumatoid arthritisSafetytsDMARD

Identifiers

PMID41343115
PMCPMC12816451

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.