Evidence map›Paper›PMID 41343944›Full record

Trial reportAddictive behaviors2026

Restricting choice of e-cigarette flavor and device type increases choices to use combusted cigarettes among adults who dual use both products: Results from a within-subjects randomized trial.

Dana Rubenstein, Lauren R Pacek, Michael J Green, Maggie M Sweitzer, Rachel Kozink, Alicia Holloway, Eric C Donny, Tracy T Smith, F Joseph McClernon

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Addictive behaviors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dana RubensteinDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27705, United States; Clinical and Translational Science Institute, Duke University School of Medicine, Durham, NC 27705, United States.
Lauren R PacekDivision of General Internal Medicine, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, United States; Rutgers Institute for Nicotine & Tobacco Studies, New Brunswick, NJ 08901, United States. Electronic address: lauren.pacek@rutgers.edu.
Michael J GreenDepartment of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC 27705, United States.
Maggie M SweitzerDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27705, United States.
Rachel KozinkDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27705, United States.
Alicia HollowayDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27705, United States.
Eric C DonnyDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States; Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States.
Tracy T SmithDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, United States.
F Joseph McClernonDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27705, United States; Clinical and Translational Science Institute, Duke University School of Medicine, Durham, NC 27705, United States.

Funding

NRSA Training CoreTL1TR002555 · NCATS · DUKE UNIVERSITY · PI EDELMAN, DAVID · 2018 to 2022
$3.7M
Impact of new standards for tobacco products among dual e-cigarette/combusted cigarette usersR01DA048454 · NIDA · DUKE UNIVERSITY · PI MCCLERNON, FRANCIS JOSEPH · 2019 to 2021
$1.4M
NCATS NIH HHS TL1 TR002555NIDA NIH HHS R01 DA048454
6 · The paper itself

Abstract

introductionData from real-world e-cigarette (EC) flavor bans suggest that such bans may increase combusted cigarette (CC) use. However, experimental data are needed to better understand how EC characteristics affect EC appeal and CC use.

methodsParticipants were adults who used both CC and flavored EC. They made 10 choices per session between taking two puffs from an EC or CC (supplied by study) or abstaining. EC type was unblinded and varied across three counterbalanced sessions: 1) own device and flavor, 2) study device with a non-tobacco-flavored e-liquid, and 3) study device with a tobacco-flavored e-liquid. Analyses evaluated EC appeal and choices to use EC, CC, or abstain.

resultsParticipants (n = 41) reported using CCs on 22.1 days/month and ECs on 26.9 days/month. Appeal of study EC was lower than participants' own EC, and participants made fewer choices for EC during tobacco-flavor EC versus own device sessions (p = 0.006). Relative to own device sessions, participants made a greater number of choices for CC when study EC were available (p's < 0.05), regardless of flavor. DISCUSSION: Regulators and public health officials should be aware that restricting EC characteristics such as device type and flavor may increase consumption of CC among people who use both products, especially people who find restricted EC less appealing than their own device. Findings are consistent with real-world sales data following EC flavor bans.

Indexed as

Choice BehaviorCigarette SmokingElectronic Nicotine Delivery SystemsFlavoring AgentsTobacco ProductsVapingAdultFemaleHumansMaleMiddle AgedYoung AdultFlavoring AgentsCigarettesDual useE-cigarettesElectronic nicotine delivery systemsTobacco regulatory science

Identifiers

PMID41343944
PMCPMC13170530

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.