Evidence map›Paper›PMID 41344632›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2026

Racial and ethnic disparities in environmental chemical exposures and hypertensive disorders of pregnancy: The ECHO-wide cohort study.

Hongxiu Liu, Amii M Kress, Emma X Yu, Xuejuan Ning, Akhgar Ghassabian, Linda G Kahn, Shilpi Mehta-Lee, Sara Brubaker, Akram Alshawabkeh, John Meeker and 32 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. T174M-M235TCurrent issues in molecular biology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Hongxiu LiuDepartment of Environmental Health, School of Environmental Science and Engineering, Hainan University; Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, PR China; Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA. Electronic address: lhx@hainanu.edu.cn.
Amii M KressDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Emma X YuDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Xuejuan NingDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Akhgar GhassabianDepartment of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA; Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA; Department of Environmental Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Linda G KahnDepartment of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA; Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Shilpi Mehta-LeeDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, NYU Langone Health, New York, NY, USA.
Sara BrubakerDepartment of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York, NY, USA.
Akram AlshawabkehCollege of Engineering, Northeastern University, Boston, MA, USA.
John MeekerUniversity of Michigan School of Public Health, Ann Arbor, MI, USA.
Carlos A CamargoMassachusetts General Hospital, Boston, MA, USA.
Shakira F SugliaDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Amy J ElliottAvera Research Institute & University of South Dakota School of Medicine, Sioux Falls, SD, USA.
Assiamira FerraraKaiser Permanente Northern California Division of Research, Oakland, CA, USA.
Yeyi ZhuKaiser Permanente Northern California Division of Research, Oakland, CA, USA.
James E GernDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Casper BendixsenMarshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, USA.
Diane R GoldChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Andrea E Cassidy-BushrowDepartment of Public Health Sciences, Henry Ford Health, Detroit, MI, USA.
Anne Marie SinghDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Shohreh F FarzanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Zhongzheng NiuDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alison E HipwellDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Margaret R KaragasDartmouth College, Geisel School of Medicine, Hanover, NH, USA.
Hooman MirzakhaniChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Thomas G O'ConnorDepartments of Psychiatry, Psychology, Neuroscience and Obstetrics & Gynecology, University of Rochester, Rochester, NY, USA.
Hyagriv SimhanDepartment of Obstetrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Emily OkenDepartment of Population Medicine, Harvard Medical School, Boston, MA, USA; Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Keia SandersonDivision of Medicine-Nephrology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Michael PetrielloInstitute of Environmental Health Sciences and Department of Pharmacology, Wayne State University, Detroit, MI, USA.
Sarah Dee GeigerDepartment of Kinesiology and Community Health, and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Kecia N CarrollThe Jack and Lucy Clark Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Grace N LawrenceGeorge Mason University, Fairfax, VA, USA.
Anne L DunlopDepartment of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
Dana DabeleaUniversity of Colorado School of Medicine, Aurora, CO, USA.
Gwendolyn NormanWayne State University, Detroit, MI, USA.
Courtney CarignanDepartment of Food Science and Human Nutrition, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
Qi ZhaoDepartment of Preventive Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.
Leonardo TrasandeDepartment of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA; Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA; Department of Environmental Medicine, NYU Grossman School of Medicine, New York, NY, USA.
program collaborators for Environmental influences on Child Health Outcomes
ECHO Components
ECHO Awardees and Cohorts

Funding

The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
The NYU Children’s Health & Environment Study: an ECHO CohortUG3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2016 to 2024
$26.5M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUH3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Andrea Aguiar, Susan L Schantz · 2018 to 2026
$18.6M
Integrative Longitudinal Genomics of Maternal Asthma-Preeclampsia Overlap and Risk of Childhood AsthmaK01HL146977 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MIRZAKHANI, HOOMAN · 2020 to 2024
$874k
Machine Learning Risk Prediction of Kidney Disease After Extremely Preterm BirthK23DK131289 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SANDERSON, KEIA · 2023 to 2025
$602k
NHLBI NIH HHS K01 HL146977NIDDK NIH HHS K23 DK131289NIH HHS UG3 OD023305NIH HHS UH3 OD023272NIH HHS UH3 OD023305
6 · The paper itself

Abstract

Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and infant mortality and morbidity worldwide. This prospective cohort study investigated the association of racial and ethnic disparities in HDP and explored the potential mediation effect of environmental chemical exposures on excess HDP risk among non-Hispanic Black pregnant people. A total of 3,279 pregnant people were included from 11 cohorts across the United States in the Environmental influences on Child Health Outcomes (ECHO) Program. We analyzed 20 environmental chemicals detected in over 70 % of biospecimens collected during pregnancy. Among Hispanic, non-Hispanic White, and non-Hispanic Black participants, 11.8 %, 10.8 %, and 16.6 % were diagnosed with HDP, respectively. Compared with non-Hispanic White participants, non-Hispanic Black participants had a higher risk of HDP (aRR = 1.48; 95 % CI 1.13-1.94) and higher levels of traditional phthalate metabolites, but lower levels of phthalate alternative metabolites and perfluorooctanoic acid. Hispanic participants had a lower risk of gestational hypertension (aRR = 0.62; 95 % CI 0.40-0.98) and lower levels of perfluoroalkyl substances than non-Hispanic White participants. Critically, despite these race/ethnicity-specific exposure patterns, individual chemical exposures did not mediate the association between racial/ethnic group and HDP. These findings highlight the need to investigate cumulative chemical mixtures and non-chemical environmental and social determinants as potential drivers of HDP disparities.

Indexed as

Environmental ExposureEnvironmental PollutantsHypertension, Pregnancy-InducedAdultCohort StudiesEthnicityFemaleHispanic or LatinoHumansPregnancyProspective StudiesUnited StatesWhiteEnvironmental PollutantsEnvironmental exposuresHypertensive disorders of pregnancyPre-pregnancy BMIRacial and ethnic disparities

Identifiers

PMID41344632
PMCPMC13242718

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.