Evidence map›Paper›PMID 41345106›Full record

ReviewNPJ systems biology and applications2025

Deciphering cell-fate trajectories using spatiotemporal single-cell transcriptomic data.

Zhenyi Zhang, Zihan Wang, Yuhao Sun, Jiantao Shen, Qiangwei Peng, Tiejun Li, Peijie Zhou

Abstract readReview
In one paragraph

Review in NPJ systems biology and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhenyi Zhang *LMAM and School of Mathematical Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0009-0009-5351-7154
Zihan Wang *Center for Quantitative Biology, Peking University, Beijing, China.
Yuhao Sun *Center for Machine Learning Research, Peking University, Beijing, China.
Jiantao Shen *Center for Machine Learning Research, Peking University, Beijing, China.
Qiangwei Peng *LMAM and School of Mathematical Sciences, Peking University, Beijing, China.
Tiejun LiLMAM and School of Mathematical Sciences, Peking University, Beijing, China. tieli@pku.edu.cn.
Peijie ZhouCenter for Quantitative Biology, Peking University, Beijing, China. pjzhou@pku.edu.cn.

Funding

National Key Research and Development Program of China 2021YFA1003301National Natural Science Foundation of China 12288101
6 · The paper itself

Abstract

Cellular processes evolve dynamically across time and space. Single-cell and spatial omics technologies have provided high-resolution snapshots of gene expression, greatly expanding the capability to characterize cellular states. This review summarizes recent modeling strategies for time-series and spatiotemporal transcriptomic data, emphasizing links between dynamical systems, generative modeling, and biological insight. These approaches illustrate how computational tools can deepen our understanding of the dynamic nature of single cells.

Indexed as

Gene Expression ProfilingSingle-Cell AnalysisTranscriptomeAnimalsComputational BiologyHumansSpatio-Temporal Analysis

Identifiers

PMID41345106
PMCPMC12764811

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.