Evidence map›Paper›PMID 41345210›Full record

Trial reportScientific reports2025

Bilateral transcutaneous auricular vagus nerve stimulation for the treatment of insomnia in breast cancer.

Melissa Do, Alexandra Evancho, William J Tyler

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06006299 (Investigating the Feasibility of Using taVNS to Treat Insomnia in Individuals With Stage I-IV Breast Cancer), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06006299 phase1completednot on this map

Investigating the Feasibility of Using taVNS to Treat Insomnia in Individuals With Stage I-IV Breast Cancer

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2023 to 2025Enrolled20ConditionsBreast Cancer, InsomniaArmstransauricular Vagus Nerve Stimulation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Melissa DoCenter for Neuroengineering and Brain Computer Interfaces, Schools of Engineering and Medicine, The University of Alabama at Birmingham (UAB), Birmingham, USA.
Alexandra EvanchoCenter for Engagement in Disability Health and Rehabilitation Sciences, UAB School of Health Professions, Birmingham, USA.
William J TylerCenter for Neuroengineering and Brain Computer Interfaces, Schools of Engineering and Medicine, The University of Alabama at Birmingham (UAB), Birmingham, USA. wjpt@uab.edu.

Funding

University of Alabama at Birmingham PREP Award
6 · The paper itself

Abstract

Substantial diagnostic and therapeutic advances have been made in medicine to address breast cancer. There remain unmet needs to translate solutions for addressing insomnia and mental health concerns in breast cancer patients. In this open-label, pilot clinical trial, we evaluated the safety and efficacy of nightly, bilateral, transcutaneous auricular vagus nerve stimulation (taVNS) on insomnia and mental health outcomes in breast cancer patients across a two-week treatment period. Our results demonstrate that noninvasive vagus nerve stimulation can significantly reduce insomnia severity, improve sleep quality, decrease sleep onset latency, and enhance sleep efficiency. Treatment with taVNS also significantly reduced the number of nightly awakenings, cancer-related fatigue, and depression scores while increasing heart rate variability. These observations demonstrate that auricular vagus nerve stimulation holds promise for improving sleep quality and mental health in patients diagnosed with breast cancer. Future investigations aimed at more thoroughly investigating the safety profile and clinical impacts of taVNS on the quality of life in patients with breast cancer are warranted.ClinicalTrials.gov Identifier: NCT06006299 23/08/2023.

Indexed as

Breast NeoplasmsSleep Initiation and Maintenance DisordersTranscutaneous Electric Nerve StimulationVagus Nerve StimulationAdultAgedFemaleHumansMiddle AgedPilot ProjectsQuality of LifeSleep QualityTreatment OutcomeBreast cancerCancerFatigueInsomniaMental healthNeuromodulationVagus nerve stimulation

Identifiers

PMID41345210
PMCPMC12783635

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.