ArticleEJNMMI physics2025
Comparison of imaging-based bone marrow dosimetry methodologies and their dose-effect relationships in [
Article in EJNMMI physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Multiple vertebrae improves precision in image-based bone marrow absorbed dose estimation in [EJNMMI physics · 2026Article
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6 authors.
Funding
Abstract
purposeEstablishing accurate methods for red marrow (RM) dosimetry is an important step toward patient-specific treatment guidance. We compared image-based dosimetry methods and investigated their role in predicting changes in blood counts following [
methodsFour image-based dosimetry methodologies were applied to patients who received 2-bed position serial
resultsImaging data was available for 20 patients for methods 1-3, while SC images were available for 12 patients for method 4. Cycle 1 AD to the FOV RM was, on average, 1.9 Gy (range: 0.1-8.0 Gy) for MIRD, 0.08 Gy (range: 0.01-0.27 Gy) for MIRD
conclusionThe RM AD estimates from the blood-based surrogate were not concordant with the other image-based calculations and did not correlate with changes in blood values. Including patient-specific tumor and marrow distribution information resulted in lower AD for patients with a high bone metastatic burden. These findings have implications for managing hematological toxicities in
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