ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026
Occurrence of ectopic ossification around the surgical site after using of ABM/P-15 in anterior cervical discectomy and fusion.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeSince receiving FDA approval in 2016, iFBG has been highlighted in several clinical studies as an innovative alternative to conventional bone graft materials. However, in our study, ectopic ossification occurred around the surgical site in the majority of cases using the iFBG. The aim of this study to describe the incidence of ectopic ossification following ACDF using i-FACTOR bone graft (iFBG) in comparison with other bone graft materials such as DBM, and to assess its influence on both clinical and radiologic outcomes.
methodsWe enrolled 153 patients and were compared clinical and radiologic data based on the presence of ectopic ossification, and multiple logistic regression was performed to determine risk factors for longitudinal dural or posterior longitudinal ligament ossification (LDPO) among patients with ectopic calcification following iFBG use.
resultsEctopic ossification occurred only in the iFBG group, with an incidence of 61.6%, while no cases were observed in the DBM group. LDPO was also confined to the iFBG group but occurred in only eight patients. Age and preoperative cervical lordosis angle were significantly associated with LDPO. Fusion rates were similar between the groups (DBM: 87.7%, iFBG: 88.9%).
conclusionsiFBG use in ACDF was associated with ectopic ossification, likely due to graft migration; however, clinical outcomes and fusion rates at one year were comparable to DBM. LDPO occurred only in the iFBG group, but its cause remains unclear and requires further study.
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