Evidence map›Paper›PMID 41345357›Full record

Trial reportInternational urology and nephrology2026

Evaluation of the efficacy and safety of different doses of daily paroxetine in patients with lifelong premature ejaculation: a prospective randomized crossover study.

Sameh Fayek GamalEl Din, Ahmed Raef Sadek, Mohamed Yousry Elamir, Mohamed Ahmed Ateya, Hesham Hanafy Saber, Mahmoud Fawzy Ghaly

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Sameh Fayek GamalEl DinDepartment of Andrology and STDs Kasr Al-Ainy, Faculty of Medicine, Cairo University, Al-Saray Street, El Manial, Cairo, 11956, Egypt. samehfayek@kasralainy.edu.eg.
Ahmed Raef SadekDepartment of Andrology and STDs Kasr Al-Ainy, Faculty of Medicine, Cairo University, Al-Saray Street, El Manial, Cairo, 11956, Egypt.
Mohamed Yousry ElamirDepartment of Andrology and STDs Kasr Al-Ainy, Faculty of Medicine, Cairo University, Al-Saray Street, El Manial, Cairo, 11956, Egypt.
Mohamed Ahmed AteyaDepartment of Urology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Hesham Hanafy SaberDepartment of Andrology and STDs Kasr Al-Ainy, Faculty of Medicine, Cairo University, Al-Saray Street, El Manial, Cairo, 11956, Egypt.
Mahmoud Fawzy GhalyDepartment of Andrology and STDs Kasr Al-Ainy, Faculty of Medicine, Cairo University, Al-Saray Street, El Manial, Cairo, 11956, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEvidence regarding the optimal dose of paroxetine for lifelong premature ejaculation (LPE) with minimal adverse effects remains limited. This study evaluated the efficacy and safety of different paroxetine doses in patients with LPE.

methodsThe study recruited 100 LPE patients. Group (A) included 50 randomized LPE patients who received 12.5 mg paroxetine daily after breakfast for 3 months. Group (B) included 50 randomized LPE patients who received 20 mg paroxetine daily after breakfast for 3 months. After a 2-week washout, a crossover was executed for 3 months.

resultsGroups A and B demonstrated statistically significant increases in the scores of the Arabic index of premature ejaculation (AIPE) and the male sexual quality of life (QOL) throughout the follow-up period. Furthermore, upper and lower bounds of 95% confidence interval using estimates of fixed effects demonstrated significant changes in sequence in group A versus group B, treatment in group A versus group B and geometric mean intravaginal ejaculation latency time (IELT) in group A versus group B (- 4.13, - 0.26; - 4.16, - 0.27; - 8.02, - 4.15; p = 0.026 0.026, 0, respectively). Notably, upper and lower bounds of 95% confidence interval using estimates of fixed effects demonstrated significant changes in the occurrence of complications in group A versus group B (- 0.35, - 0.01, p = 0.041, respectively).

conclusion12.5 mg paroxetine may be preferentially prescribed over 20 mg as it shows a comparable efficacy with lower adverse events and subsequent better tolerability and male sexual QOL.

Indexed as

ParoxetinePremature EjaculationSelective Serotonin Reuptake InhibitorsAdultCross-Over StudiesDose-Response Relationship, DrugHumansMaleMiddle AgedProspective StudiesQuality of LifeTreatment OutcomeYoung AdultParoxetineSelective Serotonin Reuptake InhibitorsDifferent doses of daily paroxetineEfficacy and safety of paroxetineGeometric mean IELTLifelong premature ejaculation

Identifiers

PMID41345357

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.