ArticleScientific reports2025
Diagnostic ultrasound-microbubble therapy promotes wound healing through miR-26b-5p-mediated GSK3β suppression.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Refractory wounds impose a significant burden on patients and society. Although diagnostic ultrasound combined with microbubble contrast agents (USMB) improves microcirculation, its role in wound healing-particularly the underlying mechanisms-remains unclear. Here, we established a rat model of acute wounds and demonstrated that USMB therapy accelerated re-epithelialization and collagen deposition, accompanied by increased CD31 and VEGF expression, reduced IL-1β and TNF-α, and elevated TGF-β. By analyzing miRNA profiles, we revealed that USMB treatment was associated with the downregulation of miR-26b-5p. This molecule may target Gsk3β, thereby affecting the PI3K/Akt/GSK-3β signaling pathway and participating in USMB-mediated wound repair. These findings clarify the potential of USMB in wound therapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.