Evidence map›Paper›PMID 41345769›Full record

ArticleScientific reports2025

Downregulation of ZBTB7A/LRF increases fetal hemoglobin expression in β

Sukanya Chumchuen, Tanapat Pornsukjantra, Pawarit Innachai, Pinyaphat Khamphikham, Chokdee Wongborisuth, Usanarat Anurathapan, Duantida Songdej, Orapan Sripichai, Amornrat Tangprasittipap, Suradej Hongeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. New Gene Therapy Strategy for β-Thalassemia.Stem cell reviews and reports · 2026
    Review
  2. Molecular and therapeutic frontiers in anemia therapy.The Journal of clinical investigation · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sukanya ChumchuenOffices of Health Science Research, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Tanapat PornsukjantraProgram in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Pawarit InnachaiOffices of Health Science Research, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Pinyaphat KhamphikhamDivision of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.
Chokdee WongborisuthOffices of Health Science Research, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Usanarat AnurathapanDepartment of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Duantida SongdejDepartment of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Orapan SripichaiDepartment of Medical Sciences, Ministry of Public Health, National Institute of Health, Nonthaburi, 11000, Thailand. osripichai@gmail.com.
Amornrat TangprasittipapOffices of Health Science Research, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand. tamornrat01@gmail.com.
Suradej HongengDepartment of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc finger and BTB domain-containing 7A (ZBTB7A) is a transcription factor repressor of fetal hemoglobin (HbF; α

Indexed as

beta-ThalassemiaDNA-Binding ProteinsErythroid CellsFetal HemoglobinHemoglobin ETranscription FactorsCell DifferentiationCell LineDown-RegulationGene Expression RegulationHumansDNA-Binding ProteinsFetal HemoglobinHemoglobin ETranscription FactorsZBTB7A protein, humanFetal hemoglobin (HbF)ZBTB7A/LRFβ-thalassemia/hemoglobin E

Identifiers

PMID41345769
PMCPMC12715185

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.