Evidence map›Paper›PMID 41345843›Full record

ArticleBMC neurology2025

Novel prognostic score based on the monocyte-to-lymphocyte ratio and CAVE score for epilepsy after primary intracerebral hemorrhage.

Weilei He, Mengmeng Xu, Ru Lin, Shu Wang, Wenjie Huang, Haisong Chen, Yunjun Yang, Jie Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Weilei He *Department of Nuclear Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Mengmeng Xu *Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ru LinDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Shu WangDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Wenjie HuangDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Haisong ChenDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yunjun YangDepartment of Nuclear Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. yangyunjun@wmu.edu.cn.
Jie LinDepartment of Nuclear Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. linjie@wmu.edu.cn.ORCID http://orcid.org/0009-0000-1139-463X

Funding

Key Laboratory of Novel Nuclide Technologies on Precision Diagnosis and Treatment & clinical Transformation of Wenzhou City 2023HZSY0012the Wenzhou Major Program of Science and Technology Innovation ZY2020012
6 · The paper itself

Abstract

backgroundNeuroinflammation-mediated epilepsy has become a focus of attention in recent years. Post-stroke epilepsy (PSE) is common, with most studies focusing on ischemic stroke rather than intracerebral hemorrhage (ICH) patients. Therefore, we aimed to determine the association between monocyte-to-lymphocyte ratio (MLR) levels and epilepsy after ICH. Additionally, we sought to develop a clinical score integrating MLR with the CAVE score to improve the risk stratification of PSE.

methodsWe retrospectively included consecutive ICH patients from January 2010 to July 2020. MLR was acquired from a routine blood test at admission. Multiple logistics and linear regression analyses were performed to identify risk factors for the PSE when MLR levels were divided into tertiles. Receiver operating characteristic (ROC) curves were used to assess the predictive accuracy of epilepsy models based on the CAVE score and the MNCAVE score.

resultsAmong the 834 patients with ICH, 47 (5.6%) patients had PSE. In multivariable logistics and linear regression analysis, elevated MLR levels were independently associated with the PSE after adjusting for several confounders (OR 2.545, 95% CI 1.036-6.255, P = 0.042). Six risk factors were selected to derive the MNCAVE score (higher MLR, severe stroke, cortical location, young age, large hematoma volume, and early seizures), which showed better prognostic performance than the conventional CAVE score (0.875 vs. 0.848, P = 0.041).

conclusionsElevated MLR levels were associated with PSE after ICH. We developed the MNCAVE score for predicting PSE, which could improve the management of patients after ICH. Inflammatory markers may provide personalized guidance for patients with varying degrees of neurological impairment.

Indexed as

Cerebral HemorrhageEpilepsyLymphocytesMonocytesAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsEpilepsyInflammationIntracerebral hemorrhageMonocyte-to-lymphocyte ratioScoreStroke severity

Identifiers

PMID41345843
PMCPMC12781339

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.