Evidence map›Paper›PMID 41345866›Full record

ArticleJournal of translational medicine2025

Associations of dietary intake for gut microbiota with frailty risk and mortality in older adults.

Da Gan, Yuyang Shi, Yunya Zhu, Xiaoyan Wang, Qihui Fu, Wenjian Liu, Haohua Yin, Luwen Liang, Bin Liu, Zi Yang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Da GanJiangxi Medicine Academy of Nutrition and Health Management, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Yuyang ShiJiangxi Medicine Academy of Nutrition and Health Management, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Yunya ZhuDepartment of General Medicine, the First Affiliated Hospital, Gannan Medical University, Ganzhou, 341000, China.
Xiaoyan WangNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Qihui FuJiangxi Medicine Academy of Nutrition and Health Management, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Wenjian LiuJiangxi Medicine Academy of Nutrition and Health Management, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Haohua YinJiangxi Medicine Academy of Nutrition and Health Management, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Luwen LiangDepartment of General Medicine, the First Affiliated Hospital, Gannan Medical University, Ganzhou, 341000, China.
Bin LiuCenter for Molecular Pathology, Department of Medical Laboratory Technology, Gannan Medical University, Ganzhou, 341000, Jiangxi, China.
Zi YangCenter for Molecular Pathology, Department of Medical Laboratory Technology, Gannan Medical University, Ganzhou, 341000, Jiangxi, China.
Xuebiao WuCenter for Molecular Pathology, Department of Medical Laboratory Technology, Gannan Medical University, Ganzhou, 341000, Jiangxi, China. China.xuebiaowu2022@163.com.
Xia HuangJiangxi Medicine Academy of Nutrition and Health Management, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. ndyfy00382@ncu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe associations between a diet that associated with a healthy gut microbiota and the risk of frailty, as well as mortality in older adults with frailty, remains unclear. Therefore, this study aimed to examine the associations of dietary index for gut microbiota (DI-GM) with frailty risk, as well as the all-cause mortality and cause-specific mortality in frail participants.

methodsA total of 6,104 participants aged 65 and older from six cycles of the National Health and Nutrition Examination Survey (2007–2018) were included in this study. DI-GM was calculated based on the intake of 13 dietary components, with a higher score reflecting a diet that associated with a more favorable gut microbiota profile. Frailty was assessed using the 48-item frailty index, and participants with a frailty index exceeding 0.21 were classified as having frailty. Mortality status and cause of death were determined through linkage to the National Death Index records until December 31, 2019. Weighted multivariable logistic regression was conducted to investigate the associations between DI-GM and the risk of frailty. Weighted multivariable Cox proportional hazards regression models were used to examine the associations of DI-GM with all-cause mortality, cardiovascular disease (CVD) mortality, and cancer mortality in frail participants.

resultsCompared with participants in the lowest DI-GM quintile, those in the highest quintile were associated with a 32% (95% confidence interval [CI]: 14% to 46%) reduced risk of frailty. Over a median 5.3 years follow-up, 778 deaths occurred among participants with frailty, including 258 deaths due to cardiovascular disease and 139 deaths due to cancer. The hazard ratios and 95% CI for all-cause mortality, CVD mortality, and cancer mortality were 0.73 (0.57, 0.93), 0.59 (0.36, 0.97), and 1.41 (0.76, 2.62), respectively, when comparing the extreme DI-GM quintiles.

conclusionDI-GM was inversely associated with the risk of frailty in older adults. Additionally, a higher DI-GM was associated with a reduced risk of all-cause mortality and CVD mortality in individuals with frailty. Diet linked to a healthy gut microbiota might be associated with a reduced risk of frailty in older adults and a decreased risk of premature mortality in individuals with frailty.

Indexed as

DietFrail ElderlyFrailtyGastrointestinal MicrobiomeAgedAged, 80 and overCardiovascular DiseasesFemaleHumansMaleNutrition SurveysProportional Hazards ModelsRisk FactorsAll-cause mortalityCardiovascular disease mortalityDietary index for gut microbiotaFrailty

Identifiers

PMID41345866
PMCPMC12797381

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.