Evidence map›Paper›PMID 41345886›Full record

ArticleEuropean journal of medical research2025

Associations of growth differentiation factor 15 with kidney function in frail and pre-frail older individuals: the mediating role of inflammation and oxidative stress.

Chi Zhang, Anying Bai, Yuting Kang, Qiang Gao, Jie Zhang, Yushan Zhang, Zehong Huo, Yingqi Zhao, Hong Shi, Ji Shen and 1 more

Abstract read
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In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chi Zhang *The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, National Center of Gerontology of National Health Commission, Beijing, 100730, China.
Anying Bai *School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Yuting KangDepartment of Science Research, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Qiang GaoDepartment of Science Research, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Jie ZhangDepartment of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Yushan ZhangDepartment of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Zehong HuoThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, National Center of Gerontology of National Health Commission, Beijing, 100730, China.
Yingqi ZhaoThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, National Center of Gerontology of National Health Commission, Beijing, 100730, China.
Hong ShiDepartment of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Ji ShenDepartment of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China. shenji4350@bjhmoh.cn.
Ping ZengThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, National Center of Gerontology of National Health Commission, Beijing, 100730, China. zengping2364@bjhmoh.cn.

Funding

National High Level Hospital Clinical Research Funding BJH-2025-253; BJ-2025-240National Science and Technology Major Project for the Prevention and Treatment of Cancer, Cardiovascular and Cerebrovascular, Respiratory and Metabolic Diseases 2024ZD0524100, 024ZD0524101
6 · The paper itself

Abstract

backgroundThis cross-sectional investigation aimed to investigate the association of plasma Growth Differentiation Factor 15 (GDF-15) with kidney function in frail and pre-frail older individuals, and to further test the mediating roles of inflammation and oxidative stress.

methods483 older adults (71.64 ± 6.07 years) with frailty or pre-frailty status were included. Plasma GDF-15 was measured using enzyme-linked immunosorbent assay. An estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m

resultsBoth the absolute concentration and the ln-transformed concentration of GDF-15 were significantly negatively correlated with eGFR (both P < 0.001). In the multivariate logistic analysis, the odds ratio (OR) of kidney dysfunction for per 1-SD increase in GDF-15 was 1.36 (95% CI 1.04-1.78). Compared with the first quartile group of GDF-15, the OR of kidney dysfunction in the third quartile group was 2.74 (95% CI 1.44-5.23, P = 0.002). Tumor necrosis factor, malondialdehyde, and glutathione peroxidase mediated the relationship between GDF-15 and eGFR, with mediating proportions of 7.23%, 8.41%, and 9.83%, respectively.

conclusionsOur findings suggest that high levels of GDF-15 are associated with lower eGFR in frail and pre-frail older individuals. GDF-15 may be related to kidney function through its involvement in inflammatory and oxidative stress responses.

Indexed as

Frail ElderlyFrailtyGrowth Differentiation Factor 15InflammationKidneyOxidative StressAgedAged, 80 and overBiomarkersCross-Sectional StudiesFemaleGlomerular Filtration RateHumansMaleBiomarkersGDF15 protein, humanGrowth Differentiation Factor 15FrailtyGlomerular filtration rateGrowth differentiation factor 15Mediation analysis

Identifiers

PMID41345886
PMCPMC12781647

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.