Evidence map›Paper›PMID 41345939›Full record

ArticleCancer cell international2025

Adaptability of lung and liver metastatic breast cancer cells to glucose.

Marjorie Anne Layosa, Madeline P Sheeley, Alekya Raghavan, Chaylen Andolino, Michael K Wendt, Stephen D Hursting, Dorothy Teegarden

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marjorie Anne LayosaDepartment of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, United States.
Madeline P SheeleyDepartment of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, United States.
Alekya RaghavanDepartment of Biological Sciences, College of Science, Purdue University, West Lafayette, United States.
Chaylen AndolinoDepartment of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, United States.
Michael K WendtDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa, United States.
Stephen D HurstingDepartment of Nutrition, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Dorothy TeegardenDepartment of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, United States. teegarden@purdue.edu.

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Indiana Clinical and Translational Science Institute (UL1)UL1TR000006 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2012 to 2013
$5.6M
Obesity, Metabolism and Breast Cancer MetastasisR01CA232589 · NCI · PURDUE UNIVERSITY · PI HURSTING, STEPHEN D, TEEGARDEN, DOROTHY · 2019 to 2023
$2.6M
Impact of hypoxia on lipid metabolism in obesity-driven breast cancer progressionR01CA271597 · NCI · PURDUE UNIVERSITY · PI Stephen D Hursting, Dorothy Teegarden · 2023 to 2026
$2.5M
Indiana Clinical Translational Science Institute NIH/NCRR (#TR000006)National Institute of Health R01CA232589 and R01CA271597NCATS NIH HHS UL1 TR000006NCI NIH HHS P30 CA023168NCI NIH HHS R01 CA232589NCI NIH HHS R01 CA271597Purdue University Institute for Cancer Research P30CA023168
6 · The paper itself

Abstract

backgroundBreast cancer is the most common cancer among women, and metastasis is the leading cause of mortality. It is still unknown how breast cancer cells metabolically adapt to successfully metastasize to different organs to survive adverse conditions, including varying nutrient availability. The purpose of this study is to elucidate the metabolic characteristics and glucose adaptation mechanisms of breast cancer cells that preferentially metastasize to the lungs or the liver.

methodsUsing a Wnt-driven breast cancer model with preferential metastasis to lung (metM-Wnt

resultsUnder normal glucose conditions, metM-Wnt

conclusionOur findings reveal that metM-Wnt

Indexed as

Breast cancerGlucoseMetabolic adaptationMetastasis

Identifiers

PMID41345939
PMCPMC12676851

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.