ArticleBMC research notes2025
The increased Bax/Bcl-2 ratio and induced apoptosis in human macrophages treated by Echinococcus granulosus hydatid cyst fluid extracellular vesicles.
Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Cytotoxic, Drug-Interaction, and Apoptosis-Associated Effects of β-Boswellic Acid and Doxorubicin in Murine 4T1 TNBC-like Cells.Biomedicines · 2026Article
- Effects of Exosomes Derived from Hydatid Cyst Stem Cells on Human Hepatocytes.Acta parasitologica · 2026Article
- Resveratrol-EnrichedNutrients · 2026Article
- Placental Barrier Breakdown Induced byInternational journal of molecular sciences · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe current study evaluated the effects of EVs from Echinococcus granulosus hydatid cyst fluid (HCF) on the expression levels of the apoptosis and autophagy factors in the THP-1 cell line. RESULTS DESCRIPTION: The morphological and blotting analyses showed extraction of intact EVs. The results of apoptosis genes showed statistically significant upregulation of CAS-7, -9, Bcl-2, and Mcl-1, while the expression of CAS-3 was significantly decreased. The expression of apoptotic factors (CAS-3, -7, and − 8) was upregulated, while the anti-apoptotic factors (Bcl-2 and Mcl-1) were significantly downregulated. In addition, the Bax/Bcl-2 ratio in 3 h was low, while it was high at 24 h. The relative expression of autophagy genes exhibited statistically significant upregulation of LC3b after 3 h. During the 24 h after exposure, the relative expression of ATG7 and ATG12 was significantly decreased. The current findings showed a low Bax/Bcl2 ratio at 3 h that was converted to high ratio at 24 h. Our findings suggested induction of apoptosis downstream of inflammatory responses of the immune system to prevent spreading of infection.
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Registered trials
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