Evidence map›Paper›PMID 41346045›Full record

ArticleEuropean journal of preventive cardiology2026

Blood pressure, proteomic vascular ageing, and incident cardiovascular disease.

Minghao Kou, Xuan Wang, Hao Ma, Yoriko Heianza, Kirsten Dorans, Lydia Bazzano, Lu Qi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Minghao KouDepartment of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA.ORCID 0000-0002-3885-4103
Xuan WangDepartment of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA.
Hao MaDepartment of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA.
Yoriko HeianzaDepartment of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA.
Kirsten DoransDepartment of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA.ORCID 0000-0002-3182-5633
Lydia BazzanoDepartment of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA.ORCID 0000-0002-8958-1352
Lu QiDepartment of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA.ORCID 0000-0002-6637-6428

Funding

Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Katherine Teresa Mills · 2016 to 2026
$25.3M
NHLBI NIH HHS HL034594NHLBI NIH HHS HL071981NHLBI NIH HHS HL126024NIDDK NIH HHS DK078616NIDDK NIH HHS DK091718NIDDK NIH HHS DK100383NIDDK NIH HHS DK115679NIGMS NIH HHS P20 GM109036NIGMS NIH HHS P20GM109036
6 · The paper itself

Abstract

aimsBlood proteomic profiling may model vascular biological ageing with high precision. This study aimed to assess the association between blood pressure and proteomic vascular ageing, and its potential mediation role in the relationship between high blood pressure and incident cardiovascular events. METHODS AND

resultsAmong 45 387 UK Biobank participants, we developed a proteomic vascular ageing signature (vascular age gap) using 21 heart- and artery-enriched proteins via a LightGBM model. Associations with vascular age gap were evaluated for blood pressure categories and continuous systolic/diastolic blood pressure (SBP/DBP). Mediation analyses examined the role of proteomic vascular ageing in the link between high blood pressure and cardiovascular events. Compared to normotensive participants, the vascular age gap was significantly higher in those with high-normal blood pressure (0.122 ± 0.048 years, P = 0.011), Grade 1 hypertension (0.266 ± 0.049 years, P < 0.001), and Grade 2 hypertension (0.494 ± 0.071 years, P < 0.001). Non-linear associations were observed for both SBP and DBP, with thresholds near 120/80 mmHg. The associations were stronger in midlife adults. The vascular age gap may mediate 3.73-10.59% of the association between Grade 2 hypertension and cardiovascular events. No mediation was observed for peripheral artery disease in Grade 2 hypertension. The most influential proteins exhibited potential mediation effects, with TNFRSF11B and CRLF1 consistently contributing to mediation across blood pressure categories and outcomes.

conclusionHigh blood pressure is associated with accelerated proteomic vascular ageing, which potentially mediates its link to cardiovascular events. This supports vascular age gap as a modest but significant marker of blood pressure-related cardiovascular risk.

Indexed as

AgingBlood PressureCardiovascular DiseasesHypertensionProteomicsAdultAgedAge FactorsBiomarkersFemaleHumansIncidenceMaleMiddle AgedRisk AssessmentRisk FactorsBiomarkersBlood pressureCardiovascular diseaseProteomicsVascular ageing

Identifiers

PMID41346045
PMCPMC13178688

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.