ArticleFrontiers in neurology2025
Association between the systemic inflammatory response index and acute ischemic stroke in young people.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The study aimed to explore the correlation between the systemic inflammatory response index (SIRI) and acute ischemic stroke in youth. Methods: A retrospective study was conducted. A total of 90 patients aged 18-45 years with acute ischemic stroke were included in the youth cerebral infarction (YCI) group, and 50 patients within the same age bracket without stroke or intracranial atherosclerosis, who were hospitalized during the same period, were included in the control group. Clinical information, blood biochemical indicators, and imaging data of the participants were analyzed. Binary logistic regression was used to assess the independent association between the SIRI and YCI. Furthermore, a subgroup analysis was performed on YCI patients. The subgroup classification included (i) infarct volume grouping; (ii) intracranial artery stenosis grouping; (iii) the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification grouping; (iv) infarct distribution grouping; and (v) vasculopathy grouping. Results: The SIRI values were higher in the YCI group compared to the control group ( Conclusion: The SIRI is independently associated with YCI and is significantly linked to severe intracranial arterial stenosis and the LAA subtype.
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