ArticleFrontiers in nutrition2025
The prognostic value of pretreatment inflammatory and nutrition-related indices in patients with cardia cancer.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the prognostic significance of inflammatory and nutrition-related indexes in patients with cardia cancer prior to treatment. Methods: A total of 229 patients with cardia cancer, diagnosed pathologically and admitted to Shanxi Cancer Hospital between January 2017 and December 2018, were included. Statistical analysis was conducted using SPSS 26.0, and the optimal cut-off values for body mass index (BMI), peripheral blood platelet-to-lymphocyte ratio (PLR), hemoglobin-to-erythrocyte distribution width ratio (HRR), prognostic nutritional index (PNI), and integrating hemoglobin, albumin, lymphocyte, and platelets (HALP) score were determined with X-tile 3.6.1 software. Survival analysis was performed using the Kaplan-Meier method, with variability assessed by the Log-rank test. Univariate and multivariate Cox proportional hazards regression analyses were used to evaluate the prognostic value of the variables. A prognostic risk stratification model was developed, incorporating age, tumor node metastasis classification (TNM), treatment options, HRR, and PNI, to classify patients into low-risk, intermediate-risk, high-risk, and very high-risk groups. The predictive value of the model was assessed using receiver operating characteristic (ROC) curves. Results: The optimal critical values of BMI, PLR, HRR, PNI, and HALP score were 20.43 kg/m Conclusion: Pre-treatment inflammatory and nutrition-related indexes, HRR and PNI, were closely associated with the prognosis of patients with cardia cancer. Combining age, TNM stage, treatment regimen, HRR, and PNI for prognostic risk stratification could significantly enhance the accuracy of prognostic predictions.
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