ArticleCureus2025
Cytotoxic and Pro-apoptotic Effects of Curcumin and Vitamin D₃ in a Human Non-Hodgkin's Lymphoma Cell Line (Daudi): An In Vitro Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Advances in Nanoparticle-Based Vitamin Delivery Systems for Precision Nutrition and Improved Bioavailability.AAPS PharmSciTech · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-Hodgkin's lymphoma (NHL) is a heterogeneous group of lymphoid malignancies, with B-cell lymphomas being the most common. Despite advances in conventional therapies, adverse effects and resistance remain major limitations, prompting interest in safer alternatives. Curcumin, a polyphenolic compound from
methodsThis in vitro study evaluated the cytotoxic and pro-apoptotic effects of curcumin and vitamin D₃, individually and in combination, on Daudi cells (a human Burkitt's lymphoma cell line). Cytotoxicity was assessed by MTT assay. Apoptosis was confirmed by DAPI nuclear staining. Quantitative reverse transcription polymerase chain reaction (RT-PCR) was performed to analyse the expression of apoptosis and cell cycle regulatory genes (
resultsCurcumin (IC₅₀ = 1.6 µM ± 0.16) and vitamin D₃ (IC₅₀ =15 µM ± 1.12) exhibited dose-dependent cytotoxicity. Combination treatment at lower doses (curcumin 0.5 µM + vitamin D₃ 7.5 µM) produced a synergistic effect (combination index 0.81). DAPI staining confirmed apoptosis in treated cells. Gene expression analysis revealed marked downregulation of the anti-apoptotic gene
conclusionCurcumin and vitamin D₃ demonstrated cytotoxic, pro-apoptotic effects in Daudi cells, both independently and in combination. Preclinical and clinical studies are warranted to validate these effects and establish translational applications.
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